Setting description

TC2 more effective in the TEfus+ signatures

Simulations setting

Survival curves (by signature)


PFS distributions (by signature)


Treatment effects (by signature)

signature var Other TC1 TC2 TC3 TC4
all param scale = 0.024, shape = 1.3 scale = 0.027, shape = 1.3 scale = 0.02, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3
all summary mean = 39, median = 31.9 mean = 34.3, median = 28 mean = 45.3, median = 37 mean = 39, median = 31.9 mean = 39, median = 31.9
all effect af = 1, hr = 1 af = 0.88, hr = 1.18 af = 1.16, hr = 0.83 af = 1, hr = 1 af = 1, hr = 1
HRD+ param scale = 0.024, shape = 1.3 scale = 0.027, shape = 1.3 scale = 0.02, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3
HRD+ summary mean = 39, median = 31.9 mean = 34.3, median = 28 mean = 47.3, median = 38.7 mean = 39, median = 31.9 mean = 39, median = 31.9
HRD+ effect af = 1, hr = 1 af = 0.88, hr = 1.18 af = 1.21, hr = 0.78 af = 1, hr = 1 af = 1, hr = 1
TP53+ param scale = 0.024, shape = 1.3 scale = 0.027, shape = 1.3 scale = 0.02, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3
TP53+ summary mean = 39, median = 31.9 mean = 34.3, median = 28 mean = 46.4, median = 37.9 mean = 39, median = 31.9 mean = 39, median = 31.9
TP53+ effect af = 1, hr = 1 af = 0.88, hr = 1.18 af = 1.19, hr = 0.8 af = 1, hr = 1 af = 1, hr = 1
TEfus+ param scale = 0.024, shape = 1.3 scale = 0.027, shape = 1.3 scale = 0.013, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3
TEfus+ summary mean = 39, median = 31.9 mean = 34.3, median = 28 mean = 70.5, median = 57.5 mean = 39, median = 31.9 mean = 39, median = 31.9
TEfus+ effect af = 1, hr = 1 af = 0.88, hr = 1.18 af = 1.8, hr = 0.46 af = 1, hr = 1 af = 1, hr = 1
PI3K+ param scale = 0.024, shape = 1.3 scale = 0.027, shape = 1.3 scale = 0.019, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3
PI3K+ summary mean = 39, median = 31.9 mean = 34.3, median = 28 mean = 49.8, median = 40.6 mean = 39, median = 31.9 mean = 39, median = 31.9
PI3K+ effect af = 1, hr = 1 af = 0.88, hr = 1.18 af = 1.27, hr = 0.73 af = 1, hr = 1 af = 1, hr = 1



Survival curves (by subgroup)


PFS distributions (by subgroup)


Treatment effects (by subgroup)

subtype var Other TC1 TC2 TC3 TC4
—- param scale = 0.024, shape = 1.3 scale = 0.027, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3
—- summary mean = 39, median = 31.9 mean = 34.3, median = 28 mean = 39, median = 31.9 mean = 39, median = 31.9 mean = 39, median = 31.9
—- effect af = 1, hr = 1 af = 0.88, hr = 1.18 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
—+ param scale = 0.024, shape = 1.3 scale = 0.027, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3
—+ summary mean = 39, median = 31.9 mean = 34.3, median = 28 mean = 39, median = 31.9 mean = 39, median = 31.9 mean = 39, median = 31.9
—+ effect af = 1, hr = 1 af = 0.88, hr = 1.18 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
–+- param scale = 0.024, shape = 1.3 scale = 0.027, shape = 1.3 scale = 0.013, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3
–+- summary mean = 39, median = 31.9 mean = 34.3, median = 28 mean = 70.5, median = 57.5 mean = 39, median = 31.9 mean = 39, median = 31.9
–+- effect af = 1, hr = 1 af = 0.88, hr = 1.18 af = 1.8, hr = 0.46 af = 1, hr = 1 af = 1, hr = 1
–++ param scale = 0.024, shape = 1.3 scale = 0.027, shape = 1.3 scale = 0.013, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3
–++ summary mean = 39, median = 31.9 mean = 34.3, median = 28 mean = 70.5, median = 57.5 mean = 39, median = 31.9 mean = 39, median = 31.9
–++ effect af = 1, hr = 1 af = 0.88, hr = 1.18 af = 1.8, hr = 0.46 af = 1, hr = 1 af = 1, hr = 1
-+– param scale = 0.024, shape = 1.3 scale = 0.027, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3
-+– summary mean = 39, median = 31.9 mean = 34.3, median = 28 mean = 39, median = 31.9 mean = 39, median = 31.9 mean = 39, median = 31.9
-+– effect af = 1, hr = 1 af = 0.88, hr = 1.18 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
-+-+ param scale = 0.024, shape = 1.3 scale = 0.027, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3
-+-+ summary mean = 39, median = 31.9 mean = 34.3, median = 28 mean = 39, median = 31.9 mean = 39, median = 31.9 mean = 39, median = 31.9
-+-+ effect af = 1, hr = 1 af = 0.88, hr = 1.18 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
-++- param scale = 0.024, shape = 1.3 scale = 0.027, shape = 1.3 scale = 0.013, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3
-++- summary mean = 39, median = 31.9 mean = 34.3, median = 28 mean = 70.5, median = 57.5 mean = 39, median = 31.9 mean = 39, median = 31.9
-++- effect af = 1, hr = 1 af = 0.88, hr = 1.18 af = 1.8, hr = 0.46 af = 1, hr = 1 af = 1, hr = 1
-+++ param scale = 0.024, shape = 1.3 scale = 0.027, shape = 1.3 scale = 0.013, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3
-+++ summary mean = 39, median = 31.9 mean = 34.3, median = 28 mean = 70.5, median = 57.5 mean = 39, median = 31.9 mean = 39, median = 31.9
-+++ effect af = 1, hr = 1 af = 0.88, hr = 1.18 af = 1.8, hr = 0.46 af = 1, hr = 1 af = 1, hr = 1
+— param scale = 0.024, shape = 1.3 scale = 0.027, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3
+— summary mean = 39, median = 31.9 mean = 34.3, median = 28 mean = 39, median = 31.9 mean = 39, median = 31.9 mean = 39, median = 31.9
+— effect af = 1, hr = 1 af = 0.88, hr = 1.18 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
+–+ param scale = 0.024, shape = 1.3 scale = 0.027, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3
+–+ summary mean = 39, median = 31.9 mean = 34.3, median = 28 mean = 39, median = 31.9 mean = 39, median = 31.9 mean = 39, median = 31.9
+–+ effect af = 1, hr = 1 af = 0.88, hr = 1.18 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
+-+- param scale = 0.024, shape = 1.3 scale = 0.027, shape = 1.3 scale = 0.013, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3
+-+- summary mean = 39, median = 31.9 mean = 34.3, median = 28 mean = 70.5, median = 57.5 mean = 39, median = 31.9 mean = 39, median = 31.9
+-+- effect af = 1, hr = 1 af = 0.88, hr = 1.18 af = 1.8, hr = 0.46 af = 1, hr = 1 af = 1, hr = 1
+-++ param scale = 0.024, shape = 1.3 scale = 0.027, shape = 1.3 scale = 0.013, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3
+-++ summary mean = 39, median = 31.9 mean = 34.3, median = 28 mean = 70.5, median = 57.5 mean = 39, median = 31.9 mean = 39, median = 31.9
+-++ effect af = 1, hr = 1 af = 0.88, hr = 1.18 af = 1.8, hr = 0.46 af = 1, hr = 1 af = 1, hr = 1
++– param scale = 0.024, shape = 1.3 scale = 0.027, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3
++– summary mean = 39, median = 31.9 mean = 34.3, median = 28 mean = 39, median = 31.9 mean = 39, median = 31.9 mean = 39, median = 31.9
++– effect af = 1, hr = 1 af = 0.88, hr = 1.18 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
++-+ param scale = 0.024, shape = 1.3 scale = 0.027, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3
++-+ summary mean = 39, median = 31.9 mean = 34.3, median = 28 mean = 39, median = 31.9 mean = 39, median = 31.9 mean = 39, median = 31.9
++-+ effect af = 1, hr = 1 af = 0.88, hr = 1.18 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
+++- param scale = 0.024, shape = 1.3 scale = 0.027, shape = 1.3 scale = 0.013, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3
+++- summary mean = 39, median = 31.9 mean = 34.3, median = 28 mean = 70.5, median = 57.5 mean = 39, median = 31.9 mean = 39, median = 31.9
+++- effect af = 1, hr = 1 af = 0.88, hr = 1.18 af = 1.8, hr = 0.46 af = 1, hr = 1 af = 1, hr = 1
++++ param scale = 0.024, shape = 1.3 scale = 0.027, shape = 1.3 scale = 0.013, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3
++++ summary mean = 39, median = 31.9 mean = 34.3, median = 28 mean = 70.5, median = 57.5 mean = 39, median = 31.9 mean = 39, median = 31.9
++++ effect af = 1, hr = 1 af = 0.88, hr = 1.18 af = 1.8, hr = 0.46 af = 1, hr = 1 af = 1, hr = 1

Errors and power


graduation (counts and proportions):
TC1 TC2 TC3 TC4
all 4 72 10 5
HRD+ 2 38 11 13
TP53+ 4 68 9 9
TEfus+ 0 279 1 3
PI3K+ 1 77 7 4
TC1 TC2 TC3 TC4
all 0.008 0.144 0.020 0.010
HRD+ 0.004 0.076 0.022 0.026
TP53+ 0.008 0.136 0.018 0.018
TEfus+ 0.000 0.558 0.002 0.006
PI3K+ 0.002 0.154 0.014 0.008
futility (counts and proportions):
TC1 TC2 TC3 TC4
all 49 0 3 3
HRD+ 10 1 16 11
TP53+ 185 10 86 77
TEfus+ 219 0 142 121
PI3K+ 160 0 70 91
TC1 TC2 TC3 TC4
all 0.098 0.000 0.006 0.006
HRD+ 0.020 0.002 0.032 0.022
TP53+ 0.370 0.020 0.172 0.154
TEfus+ 0.438 0.000 0.284 0.242
PI3K+ 0.320 0.000 0.140 0.182
max sample size (counts and proportions):
TC1 TC2 TC3 TC4
all 0 0 0 0
HRD+ 0 0 0 0
TP53+ 0 0 0 0
TEfus+ 0 0 0 0
PI3K+ 0 0 0 0
TC1 TC2 TC3 TC4
all 0 0 0 0
HRD+ 0 0 0 0
TP53+ 0 0 0 0
TEfus+ 0 0 0 0
PI3K+ 0 0 0 0


Operating characteristics

Characteristics Overall TC1 TC2 TC3 TC4
Error signature 0.306 0.022 0.178 0.07 0.064
Error subgroup 0.484 0.022 0.382 0.07 0.064
Power signature 0.558 0.000 0.558 0.00 0.000
Power subgroup 0.736 0.000 0.736 0.00 0.000

Median results at the end of the trial

By signature:
signature var Control TC1 TC2 TC3 TC4
all graduation 0 4 72 10 5
all futility 0 49 0 3 3
all max_n 0 0 0 0 0
all n 615 (569, 666) 227 (160, 329) 319 (192, 429) 306 (214, 416) 316 (227, 420)
all n_unique 615 (569, 666) 227 (160, 329) 319 (192, 429) 306 (214, 416) 316 (227, 420)
all time_trial 60 (60, 60) 60 (60, 60) 60 (42, 60) 60 (60, 60) 60 (60, 60)
all time_stop NA (NA, NA) 42 (16, 58) 30 (11, 55) 19 (12, 56) 18 (11, 36)
all post_p NA (NA, NA) 0.04 (0, 0.3) 0.99 (0.83, 1) 0.44 (0.08, 0.86) 0.45 (0.08, 0.9)
all rate 0.02 (0.019, 0.022) 0.025 (0.023, 0.029) 0.017 (0.015, 0.019) 0.021 (0.019, 0.024) 0.021 (0.019, 0.024)
HRD+ graduation 0 2 38 11 13
HRD+ futility 0 10 1 16 11
HRD+ max_n 0 0 0 0 0
HRD+ n 83 (70, 99) 37 (23, 55) 43 (22, 60) 49 (33, 68) 45 (29, 65)
HRD+ n_unique 83 (70, 99) 37 (23, 55) 43 (22, 60) 49 (33, 68) 45 (29, 65)
HRD+ time_trial 60 (60, 60) 60 (60, 60) 60 (60, 60) 60 (60, 60) 60 (60, 60)
HRD+ time_stop NA (NA, NA) 57 (52, 60) 52 (43, 58) 52 (42, 58) 56 (42, 59)
HRD+ post_p NA (NA, NA) 0.24 (0.03, 0.7) 0.81 (0.39, 0.97) 0.46 (0.1, 0.84) 0.44 (0.08, 0.83)
HRD+ rate 0.02 (0.016, 0.025) 0.025 (0.019, 0.035) 0.016 (0.012, 0.022) 0.021 (0.017, 0.028) 0.021 (0.016, 0.029)
TP53+ graduation 0 4 68 9 9
TP53+ futility 0 185 10 86 77
TP53+ max_n 0 0 0 0 0
TP53+ n 228 (200, 254) 84 (51, 133) 118 (65, 172) 112 (61, 163) 118 (62, 166)
TP53+ n_unique 228 (200, 254) 84 (51, 133) 118 (65, 172) 112 (61, 163) 118 (62, 166)
TP53+ time_trial 60 (60, 60) 60 (34, 60) 60 (44, 60) 60 (41, 60) 60 (39, 60)
TP53+ time_stop NA (NA, NA) 41 (28, 56) 39 (24, 54) 41 (29, 56) 35 (25, 54)
TP53+ post_p NA (NA, NA) 0.14 (0.01, 0.55) 0.94 (0.61, 1) 0.44 (0.08, 0.86) 0.45 (0.1, 0.85)
TP53+ rate 0.02 (0.018, 0.023) 0.025 (0.021, 0.031) 0.016 (0.014, 0.02) 0.021 (0.018, 0.025) 0.021 (0.018, 0.026)
TEfus+ graduation 0 0 279 1 3
TEfus+ futility 0 219 0 142 121
TEfus+ max_n 0 0 0 0 0
TEfus+ n 202 (177, 225) 70 (50, 113) 111 (54, 172) 90 (54, 142) 90 (56, 146)
TEfus+ n_unique 202 (177, 225) 70 (50, 113) 111 (54, 172) 90 (54, 142) 90 (56, 146)
TEfus+ time_trial 60 (60, 60) 60 (37, 60) 54 (30, 60) 60 (40, 60) 60 (42, 60)
TEfus+ time_stop NA (NA, NA) 45 (33, 56) 38 (26, 55) 44 (32, 57) 44 (31, 56)
TEfus+ post_p NA (NA, NA) 0.04 (0, 0.3) 1 (0.95, 1) 0.17 (0.01, 0.61) 0.18 (0.01, 0.63)
TEfus+ rate 0.018 (0.015, 0.02) 0.025 (0.021, 0.031) 0.01 (0.008, 0.013) 0.022 (0.018, 0.026) 0.021 (0.018, 0.026)
PI3K+ graduation 0 1 77 7 4
PI3K+ futility 0 160 0 70 91
PI3K+ max_n 0 0 0 0 0
PI3K+ n 215 (191, 238) 80 (50, 122) 112 (60, 166) 104 (58, 154) 110 (59, 159)
PI3K+ n_unique 215 (191, 238) 80 (50, 122) 112 (60, 166) 104 (58, 154) 110 (59, 159)
PI3K+ time_trial 60 (60, 60) 60 (36, 60) 60 (46, 60) 60 (46, 60) 60 (36, 60)
PI3K+ time_stop NA (NA, NA) 43 (30, 55) 41 (28, 56) 40 (30, 54) 34 (24, 54)
PI3K+ post_p NA (NA, NA) 0.1 (0.01, 0.45) 0.96 (0.74, 1) 0.35 (0.07, 0.8) 0.33 (0.07, 0.81)
PI3K+ rate 0.02 (0.017, 0.022) 0.025 (0.021, 0.032) 0.015 (0.012, 0.018) 0.021 (0.018, 0.026) 0.021 (0.018, 0.026)


By subgroup combinations:
subtype var Control TC1 TC2 TC3 TC4
—- graduation 0 4 72 10 5
—- futility 0 49 0 3 3
—- max_n 0 0 0 0 0
—- n 189 (159, 222) 54 (26, 123) 78 (28, 166) 90 (31, 167) 100 (33, 175)
—- n_unique 189 (159, 222) 54 (26, 123) 78 (28, 166) 90 (31, 167) 100 (33, 175)
—- post_p NA (NA, NA) 0.24 (0.03, 0.68) 0.54 (0.14, 0.93) 0.54 (0.14, 0.92) 0.58 (0.14, 0.94)
—- rate 0.022 (0.019, 0.025) 0.026 (0.022, 0.035) 0.022 (0.018, 0.029) 0.022 (0.017, 0.029) 0.021 (0.017, 0.029)
—+ graduation 0 5 131 17 9
—+ futility 0 180 0 70 92
—+ max_n 0 0 0 0 0
—+ n 43 (33, 55) 16 (8, 33) 18 (7, 37) 21 (9, 43) 22 (9, 43)
—+ n_unique 43 (33, 55) 16 (8, 33) 18 (7, 37) 21 (9, 43) 22 (9, 43)
—+ post_p NA (NA, NA) 0.34 (0.1, 0.74) 0.55 (0.18, 0.88) 0.56 (0.17, 0.9) 0.52 (0.15, 0.9)
—+ rate 0.022 (0.016, 0.029) 0.027 (0.018, 0.04) 0.021 (0.014, 0.034) 0.021 (0.014, 0.035) 0.023 (0.015, 0.036)
–+- graduation 0 4 322 11 8
–+- futility 0 236 0 142 122
–+- max_n 0 0 0 0 0
–+- n 12 (8, 18) 6 (3, 11) 7 (3, 13) 6 (3, 13) 7 (3, 12)
–+- n_unique 12 (8, 18) 6 (3, 11) 7 (3, 13) 6 (3, 13) 7 (3, 12)
–+- post_p NA (NA, NA) 0.36 (0.14, 0.62) 0.66 (0.39, 0.88) 0.45 (0.19, 0.73) 0.45 (0.19, 0.71)
–+- rate 0.017 (0.008, 0.028) 0.026 (0.012, 0.055) 0.01 (0.002, 0.025) 0.022 (0.008, 0.047) 0.021 (0.008, 0.05)
–++ graduation 0 5 342 17 12
–++ futility 0 300 0 174 176
–++ max_n 0 0 0 0 0
–++ n 68 (55, 81) 18 (8, 42) 37 (16, 66) 22 (10, 54) 24 (12, 57)
–++ n_unique 68 (55, 81) 18 (8, 42) 37 (16, 66) 22 (10, 54) 24 (12, 57)
–++ post_p NA (NA, NA) 0.17 (0.03, 0.52) 0.94 (0.72, 1) 0.3 (0.06, 0.73) 0.28 (0.06, 0.7)
–++ rate 0.018 (0.013, 0.022) 0.027 (0.018, 0.042) 0.01 (0.007, 0.015) 0.022 (0.015, 0.034) 0.023 (0.016, 0.032)
-+– graduation 0 7 123 19 14
-+– futility 0 197 9 86 78
-+– max_n 0 0 0 0 0
-+– n 79 (63, 96) 26 (12, 57) 34 (16, 69) 37 (13, 71) 41 (15, 70)
-+– n_unique 79 (63, 96) 26 (12, 57) 34 (16, 69) 37 (13, 71) 41 (15, 70)
-+– post_p NA (NA, NA) 0.33 (0.07, 0.73) 0.56 (0.15, 0.92) 0.57 (0.15, 0.92) 0.58 (0.16, 0.92)
-+– rate 0.022 (0.018, 0.027) 0.026 (0.02, 0.037) 0.022 (0.016, 0.031) 0.021 (0.015, 0.033) 0.021 (0.016, 0.033)
-+-+ graduation 0 7 163 24 17
-+-+ futility 0 264 9 127 134
-+-+ max_n 0 0 0 0 0
-+-+ n 52 (41, 65) 17 (8, 40) 22 (10, 46) 25 (9, 50) 26 (11, 51)
-+-+ n_unique 52 (41, 65) 17 (8, 40) 22 (10, 46) 25 (9, 50) 26 (11, 51)
-+-+ post_p NA (NA, NA) 0.36 (0.07, 0.73) 0.56 (0.18, 0.89) 0.54 (0.15, 0.87) 0.55 (0.17, 0.88)
-+-+ rate 0.022 (0.017, 0.028) 0.026 (0.018, 0.042) 0.022 (0.016, 0.034) 0.022 (0.015, 0.035) 0.022 (0.015, 0.034)
-++- graduation 0 7 342 19 17
-++- futility 0 325 6 198 171
-++- max_n 0 0 0 0 0
-++- n 49 (38, 61) 14 (7, 32) 26 (11, 50) 18 (8, 39) 18 (8, 39)
-++- n_unique 49 (38, 61) 14 (7, 32) 26 (11, 50) 18 (8, 39) 18 (8, 39)
-++- post_p NA (NA, NA) 0.23 (0.05, 0.61) 0.91 (0.6, 0.99) 0.31 (0.07, 0.76) 0.34 (0.07, 0.76)
-++- rate 0.018 (0.013, 0.023) 0.026 (0.017, 0.04) 0.011 (0.006, 0.016) 0.022 (0.014, 0.036) 0.022 (0.014, 0.035)
-+++ graduation 0 7 355 23 20
-+++ futility 0 360 6 218 208
-+++ max_n 0 0 0 0 0
-+++ n 37 (28, 47) 12 (6, 28) 18 (7, 35) 15 (7, 33) 16 (7, 36)
-+++ n_unique 37 (28, 47) 12 (6, 28) 18 (7, 35) 15 (7, 33) 16 (7, 36)
-+++ post_p NA (NA, NA) 0.23 (0.05, 0.6) 0.88 (0.56, 0.99) 0.34 (0.1, 0.72) 0.37 (0.08, 0.72)
-+++ rate 0.017 (0.012, 0.024) 0.026 (0.015, 0.043) 0.01 (0.005, 0.017) 0.022 (0.013, 0.035) 0.022 (0.014, 0.036)
+— graduation 0 6 108 21 18
+— futility 0 59 1 19 14
+— max_n 0 0 0 0 0
+— n 39 (31, 50) 15 (7, 31) 18 (7, 33) 23 (12, 39) 20 (9, 36)
+— n_unique 39 (31, 50) 15 (7, 31) 18 (7, 33) 23 (12, 39) 20 (9, 36)
+— post_p NA (NA, NA) 0.4 (0.09, 0.81) 0.56 (0.18, 0.89) 0.57 (0.17, 0.88) 0.53 (0.16, 0.88)
+— rate 0.023 (0.016, 0.029) 0.026 (0.015, 0.044) 0.021 (0.013, 0.034) 0.022 (0.015, 0.032) 0.022 (0.013, 0.036)
+–+ graduation 0 7 161 28 22
+–+ futility 0 184 1 85 102
+–+ max_n 0 0 0 0 0
+–+ n 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
+–+ n_unique 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
+–+ post_p NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
+–+ rate 0.032 (0, 0.139) 0.063 (0.063, 0.063) 0 (0, 0) 0.143 (0.093, 0.193) 0.118 (0.118, 0.118)
+-+- graduation 0 6 340 21 20
+-+- futility 0 241 1 153 131
+-+- max_n 0 0 0 0 0
+-+- n 29 (21, 37) 11 (5, 23) 13 (4, 26) 14 (7, 26) 13 (6, 26)
+-+- n_unique 29 (21, 37) 11 (5, 23) 13 (4, 26) 14 (7, 26) 13 (6, 26)
+-+- post_p NA (NA, NA) 0.26 (0.07, 0.63) 0.8 (0.43, 0.97) 0.35 (0.09, 0.74) 0.36 (0.1, 0.76)
+-+- rate 0.017 (0.012, 0.026) 0.026 (0.015, 0.047) 0.01 (0.004, 0.021) 0.023 (0.014, 0.038) 0.022 (0.012, 0.039)
+-++ graduation 0 7 356 27 24
+-++ futility 0 303 1 184 184
+-++ max_n 0 0 0 0 0
+-++ n 6 (3, 10) 3 (1, 6) 3 (0, 6) 4 (1, 7) 4 (1, 8)
+-++ n_unique 6 (3, 10) 3 (1, 6) 3 (0, 6) 4 (1, 7) 4 (1, 8)
+-++ post_p NA (NA, NA) 0.44 (0.28, 0.63) 0.58 (0.43, 0.75) 0.47 (0.3, 0.64) 0.46 (0.32, 0.65)
+-++ rate 0.017 (0, 0.04) 0.027 (0, 0.07) 0.009 (0, 0.033) 0.023 (0.006, 0.056) 0.023 (0, 0.054)
++– graduation 0 9 154 29 26
++– futility 0 201 8 99 88
++– max_n 0 0 0 0 0
++– n 1 (0, 3) 0 (0, 2) 0 (0, 2) 1 (0, 2) 1 (0, 2)
++– n_unique 1 (0, 3) 0 (0, 2) 0 (0, 2) 1 (0, 2) 1 (0, 2)
++– post_p NA (NA, NA) 0.5 (0.42, 0.57) 0.5 (0.43, 0.56) 0.5 (0.43, 0.57) 0.5 (0.43, 0.58)
++– rate 0.022 (0, 0.093) 0.024 (0, 0.089) 0.02 (0, 0.091) 0.019 (0, 0.094) 0.016 (0, 0.087)
++-+ graduation 0 9 190 34 29
++-+ futility 0 265 8 139 143
++-+ max_n 0 0 0 0 0
++-+ n 8 (4, 12) 4 (1, 7) 4 (1, 8) 5 (2, 9) 5 (2, 10)
++-+ n_unique 8 (4, 12) 4 (1, 7) 4 (1, 8) 5 (2, 9) 5 (2, 10)
++-+ post_p NA (NA, NA) 0.44 (0.25, 0.71) 0.51 (0.3, 0.76) 0.5 (0.25, 0.75) 0.49 (0.25, 0.73)
++-+ rate 0.022 (0.01, 0.044) 0.028 (0.008, 0.067) 0.022 (0, 0.056) 0.023 (0.008, 0.055) 0.024 (0.009, 0.052)
+++- graduation 0 9 357 28 28
+++- futility 0 327 5 208 180
+++- max_n 0 0 0 0 0
+++- n 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
+++- n_unique 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
+++- post_p NA (NA, NA) NA (NA, NA) 0.55 (0.55, 0.55) NA (NA, NA) 0.49 (0.49, 0.49)
+++- rate 0.033 (0.031, 0.075) 0.026 (0.005, 0.046) 0 (0, 0) 0 (0, 0.045) 0.037 (0.037, 0.037)
++++ graduation 0 9 367 32 31
++++ futility 0 361 5 227 216
++++ max_n 0 0 0 0 0
++++ n 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
++++ n_unique 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
++++ post_p NA (NA, NA) 0.5 (0.46, 0.53) 0.45 (0.45, 0.45) 0.46 (0.46, 0.46) 0.51 (0.51, 0.51)
++++ rate 0.018 (0, 0.177) 0 (0, 0.06) 0 (0, 0.109) 0.03 (0, 0.154) 0 (0, 0.053)

Median results over time

Signatures:

Posterior probabilities

Randomization probabilities

PFS rates


Subgroup combinations:

Posterior probabilities

Randomization probabilities

PFS rates

Median results at stop

By signature

Graduation:
signature var TC1 TC2 TC3 TC4
all count 4 72 10 5
all time_stop 12 (10, 21) 30 (11, 55) 14 (12, 24) 14 (12, 22)
all n_trt 68 (57, 128) 176 (68, 319) 80 (61, 147) 72 (60, 113)
all n_control 102 (83, 169) 266 (92, 546) 112 (99, 208) 113 (96, 200)
all post_p 0.92 (0.9, 0.97) 0.98 (0.89, 1) 0.95 (0.9, 0.97) 0.87 (0.86, 0.97)
all order 1 (1, 1) 1 (1, 3) 1 (1, 1.1) 1 (1, 1)
HRD+ count 2 38 11 13
HRD+ time_stop 50 (43, 56) 52 (43, 58) 49 (42, 57) 54 (42, 60)
HRD+ n_trt 56 (55, 56) 52 (50, 61) 52 (50, 68) 54 (50, 64)
HRD+ n_control 58 (51, 64) 66 (54, 85) 64 (47, 90) 69 (58, 79)
HRD+ post_p 0.9 (0.89, 0.91) 0.94 (0.88, 0.98) 0.96 (0.91, 0.98) 0.93 (0.88, 0.98)
HRD+ order 2 (1.2, 2.8) 1 (1, 2.3) 1 (1, 2) 2 (1, 2)
TP53+ count 4 68 9 9
TP53+ time_stop 25 (23, 27) 42 (28, 55) 29 (24, 47) 35 (26, 47)
TP53+ n_trt 50 (50, 54) 99 (66, 152) 57 (51, 118) 73 (56, 133)
TP53+ n_control 70 (60, 85) 138 (79, 196) 100 (75, 154) 124 (87, 167)
TP53+ post_p 0.92 (0.9, 0.97) 0.98 (0.93, 1) 0.99 (0.97, 1) 0.96 (0.93, 0.99)
TP53+ order 1 (1, 1) 1 (1, 3) 1 (1, 1) 1 (1, 2.2)
TEfus+ count 279 1 3
TEfus+ time_stop 38 (26, 55) 34 (34, 34) 29 (25, 35)
TEfus+ n_trt 90 (57, 147) 52 (52, 52) 59 (57, 61)
TEfus+ n_control 112 (67, 176) 102 (102, 102) 86 (72, 103)
TEfus+ post_p 0.99 (0.94, 1) 0.94 (0.94, 0.94) 0.93 (0.9, 0.98)
TEfus+ order 1 (1, 2) 1 (1, 1) 1 (1, 1)
PI3K+ count 1 77 7 4
PI3K+ time_stop 35 (35, 35) 41 (28, 56) 33 (31, 42) 28 (23, 49)
PI3K+ n_trt 74 (74, 74) 87 (53, 129) 65 (54, 72) 62 (56, 157)
PI3K+ n_control 119 (119, 119) 125 (76, 207) 101 (85, 158) 70 (66, 165)
PI3K+ post_p 0.91 (0.91, 0.91) 0.99 (0.94, 1) 0.95 (0.9, 0.99) 0.93 (0.88, 0.99)
PI3K+ order 1 (1, 1) 2 (1, 3.4) 2 (1, 2) 1.5 (1, 2.7)
Futility:
signature var TC1 TC2 TC3 TC4
all count 49 3 3
all time_stop 46 (21, 58) 58 (48, 59) 30 (13, 45)
all n_trt 159 (94, 229) 193 (168, 231) 122 (68, 145)
all n_control 436 (166, 602) 608 (472, 612) 249 (107, 451)
all post_p 0 (0, 0.03) 0 (0, 0.02) 0.13 (0.03, 0.22)
all order 3 (1, 6) 3 (2.2, 3.8) 2 (1.2, 3.6)
HRD+ count 10 1 16 11
HRD+ time_stop 57 (56, 60) 58 (58, 58) 54 (42, 59) 57 (53, 58)
HRD+ n_trt 54 (50, 61) 61 (61, 61) 53 (50, 58) 54 (50, 63)
HRD+ n_control 82 (74, 88) 90 (90, 90) 71 (52, 86) 82 (76, 87)
HRD+ post_p 0.06 (0.03, 0.19) 0.2 (0.2, 0.2) 0.19 (0.01, 0.28) 0.14 (0.06, 0.24)
HRD+ order 3.5 (2, 6) 5 (5, 5) 3 (1, 4.5) 3 (2, 5)
TP53+ count 185 10 86 77
TP53+ time_stop 41 (29, 56) 24 (22, 41) 41 (30, 56) 35 (25, 53)
TP53+ n_trt 69 (51, 108) 61 (52, 84) 69 (51, 112) 62 (51, 87)
TP53+ n_control 140 (90, 210) 80 (65, 141) 146 (99, 213) 121 (76, 199)
TP53+ post_p 0.07 (0.01, 0.2) 0.21 (0.02, 0.28) 0.11 (0.04, 0.21) 0.14 (0.03, 0.23)
TP53+ order 2 (1, 4) 1 (1, 1.4) 2 (1, 4) 1 (1, 3)
TEfus+ count 219 142 121
TEfus+ time_stop 45 (33, 56) 44 (32, 57) 44 (32, 56)
TEfus+ n_trt 61 (51, 92) 63 (51, 101) 66 (51, 98)
TEfus+ n_control 139 (89, 191) 134 (92, 190) 139 (80, 189)
TEfus+ post_p 0.04 (0, 0.16) 0.05 (0.01, 0.18) 0.06 (0, 0.2)
TEfus+ order 2 (1, 4) 2 (1, 4) 2 (1, 4)
PI3K+ count 160 70 91
PI3K+ time_stop 44 (30, 55) 41 (30, 54) 35 (24, 53)
PI3K+ n_trt 65 (50, 103) 62 (50, 99) 63 (51, 95)
PI3K+ n_control 147 (87, 199) 134 (78, 185) 99 (66, 189)
PI3K+ post_p 0.04 (0.01, 0.19) 0.09 (0.01, 0.22) 0.09 (0.02, 0.25)
PI3K+ order 2 (1, 4) 2 (1, 4) 2 (1, 4)


By subgroup combinations

Graduation:
signature treatment var —- —+ –+- –++ -+– -+-+ -++- -+++ +— +–+ +-+- +-++ ++– ++-+ +++- ++++
all TC1 count 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4
all TC1 time 12 (10, 21) 12 (10, 21) 12 (10, 21) 12 (10, 21) 12 (10, 21) 12 (10, 21) 12 (10, 21) 12 (10, 21) 12 (10, 21) 12 (10, 21) 12 (10, 21) 12 (10, 21) 12 (10, 21) 12 (10, 21) 12 (10, 21) 12 (10, 21)
all TC1 n 34 (23, 48) 4 (3, 9) 0 (0, 2) 7 (6, 18) 10 (9, 11) 4 (2, 17) 6 (5, 10) 3 (1, 8) 2 (1, 3) 0 (0, 0) 1 (0, 3) 0 (0, 1) 0 (0, 0) 1 (0, 3) 0 (0, 0) 0 (0, 0)
all TC1 post_p 0.56 (0.55, 0.6) 0.55 (0.53, 0.56) 0.52 (0.52, 0.52) 0.52 (0.51, 0.56) 0.57 (0.52, 0.65) 0.56 (0.52, 0.78) 0.55 (0.53, 0.58) 0.51 (0.51, 0.52) 0.52 (0.51, 0.55) NA (NA, NA) 0.53 (0.53, 0.54) NA (NA, NA) NA (NA, NA) 0.51 (0.51, 0.52) NA (NA, NA) NA (NA, NA)
all TC1 r_prob 0.37 (0.37, 0.37) 0.27 (0.27, 0.27) 0.18 (0.18, 0.18) 0.07 (0.07, 0.07) 0.18 (0.18, 0.18) 0.07 (0.07, 0.07) 0.12 (0.12, 0.12) 0.06 (0.06, 0.06) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
all TC1 rate 0.011 (0.009, 0.014) 0 (0, 0.006) 0 (0, 0) 0.005 (0, 0.017) 0 (0, 0.013) 0 (0, 0) 0.004 (0, 0.016) 0 (0, 0.011) 0 (0, 0) NA (NA, NA) 0 (0, 0) 0 (0, 0) NA (NA, NA) 0 (0, 0) NA (NA, NA) NA (NA, NA)
all TC2 count 72 72 72 72 72 72 72 72 72 72 72 72 72 72 72 72
all TC2 time 30 (11, 55) 30 (11, 55) 30 (11, 55) 30 (11, 55) 30 (11, 55) 30 (11, 55) 30 (11, 55) 30 (11, 55) 30 (11, 55) 30 (11, 55) 30 (11, 55) 30 (11, 55) 30 (11, 55) 30 (11, 55) 30 (11, 55) 30 (11, 55)
all TC2 n 42 (22, 102) 12 (1, 30) 4 (1, 9) 18 (6, 41) 24 (11, 39) 12 (6, 36) 14 (7, 30) 9 (4, 21) 10 (1, 23) 0 (0, 0) 6 (1, 14) 1 (0, 4) 0 (0, 1) 2 (0, 5) 0 (0, 0) 0 (0, 0)
all TC2 post_p 0.67 (0.55, 0.9) 0.61 (0.51, 0.79) 0.55 (0.51, 0.78) 0.69 (0.52, 0.96) 0.61 (0.52, 0.89) 0.58 (0.51, 0.85) 0.62 (0.52, 0.91) 0.57 (0.52, 0.91) 0.58 (0.51, 0.82) NA (NA, NA) 0.58 (0.52, 0.89) 0.54 (0.51, 0.61) 0.53 (0.51, 0.56) 0.54 (0.5, 0.63) NA (NA, NA) 0.5 (0.5, 0.5)
all TC2 r_prob 0.25 (0.25, 0.25) 0.07 (0.07, 0.07) 0.41 (0.41, 0.41) 0.27 (0.27, 0.27) 0.41 (0.41, 0.41) 0.27 (0.27, 0.27) 0.41 (0.41, 0.41) 0.25 (0.25, 0.25) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
all TC2 rate 0.015 (0, 0.022) 0.013 (0, 0.023) 0 (0, 0.015) 0.007 (0, 0.014) 0.015 (0, 0.022) 0.013 (0, 0.02) 0.008 (0, 0.014) 0.006 (0, 0.014) 0.009 (0, 0.021) NA (NA, NA) 0 (0, 0.015) 0 (0, 0.023) 0 (0, 0.032) 0 (0, 0.029) NA (NA, NA) 0.307 (0.061, 0.553)
all TC3 count 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10
all TC3 time 14 (12, 24) 14 (12, 24) 14 (12, 24) 14 (12, 24) 14 (12, 24) 14 (12, 24) 14 (12, 24) 14 (12, 24) 14 (12, 24) 14 (12, 24) 14 (12, 24) 14 (12, 24) 14 (12, 24) 14 (12, 24) 14 (12, 24) 14 (12, 24)
all TC3 n 25 (17, 40) 7 (4, 15) 2 (0, 3) 8 (4, 16) 10 (5, 20) 4 (3, 14) 7 (2, 11) 6 (1, 10) 10 (6, 10) 0 (0, 0) 10 (5, 14) 1 (0, 3) 0 (0, 1) 1 (0, 2) 0 (0, 0) 0 (0, 0)
all TC3 post_p 0.67 (0.54, 0.81) 0.54 (0.51, 0.6) 0.51 (0.51, 0.53) 0.53 (0.51, 0.61) 0.57 (0.53, 0.72) 0.54 (0.51, 0.59) 0.55 (0.52, 0.69) 0.55 (0.51, 0.6) 0.54 (0.52, 0.6) NA (NA, NA) 0.53 (0.52, 0.62) 0.55 (0.53, 0.58) 0.51 (0.5, 0.52) 0.51 (0.5, 0.53) NA (NA, NA) NA (NA, NA)
all TC3 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.5 (0.5, 0.5) 0.33 (0.33, 0.33) 0.5 (0.5, 0.5) 0.33 (0.33, 0.33) 0.5 (0.5, 0.5) 0.33 (0.33, 0.33) 0.5 (0.5, 0.5) 0.33 (0.33, 0.33)
all TC3 rate 0.008 (0, 0.014) 0 (0, 0.022) 0 (0, 0.006) 0 (0, 0.017) 0 (0, 0.022) 0 (0, 0.015) 0 (0, 0.001) 0 (0, 0.013) 0.005 (0, 0.021) NA (NA, NA) 0 (0, 0.015) 0 (0, 0) 0 (0, 0) 0 (0, 0.008) NA (NA, NA) NA (NA, NA)
all TC4 count 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5
all TC4 time 14 (12, 22) 14 (12, 22) 14 (12, 22) 14 (12, 22) 14 (12, 22) 14 (12, 22) 14 (12, 22) 14 (12, 22) 14 (12, 22) 14 (12, 22) 14 (12, 22) 14 (12, 22) 14 (12, 22) 14 (12, 22) 14 (12, 22) 14 (12, 22)
all TC4 n 28 (13, 36) 8 (2, 10) 1 (0, 3) 13 (8, 16) 8 (3, 13) 9 (5, 11) 6 (5, 8) 5 (3, 9) 2 (2, 7) 0 (0, 0) 4 (1, 7) 1 (0, 2) 0 (0, 1) 1 (0, 2) 0 (0, 0) 0 (0, 0)
all TC4 post_p 0.59 (0.55, 0.78) 0.53 (0.52, 0.56) 0.54 (0.52, 0.57) 0.59 (0.55, 0.64) 0.56 (0.52, 0.58) 0.56 (0.51, 0.58) 0.53 (0.5, 0.6) 0.56 (0.53, 0.57) 0.54 (0.52, 0.56) NA (NA, NA) 0.51 (0.51, 0.53) 0.52 (0.51, 0.52) NA (NA, NA) 0.52 (0.51, 0.53) NA (NA, NA) NA (NA, NA)
all TC4 r_prob 0 (0, 0) 0.33 (0.33, 0.33) 0 (0, 0) 0.33 (0.33, 0.33) 0 (0, 0) 0.33 (0.33, 0.33) 0 (0, 0) 0.31 (0.31, 0.31) 0 (0, 0) 0.33 (0.33, 0.33) 0 (0, 0) 0.33 (0.33, 0.33) 0 (0, 0) 0.33 (0.33, 0.33) 0 (0, 0) 0.33 (0.33, 0.33)
all TC4 rate 0.006 (0, 0.012) 0 (0, 0.008) 0 (0, 0) 0 (0, 0.008) 0 (0, 0.01) 0.014 (0, 0.021) 0 (0, 0) 0 (0, 0.011) 0 (0, 0.011) NA (NA, NA) 0 (0, 0.01) 0 (0, 0) 0 (0, 0) 0 (0, 0) NA (NA, NA) NA (NA, NA)
HRD+ TC1 count 2 2 2 2 2 2 2 2
HRD+ TC1 time 50 (43, 56) 50 (43, 56) 50 (43, 56) 50 (43, 56) 50 (43, 56) 50 (43, 56) 50 (43, 56) 50 (43, 56)
HRD+ TC1 n 20 (19, 20) 0 (0, 0) 22 (21, 24) 6 (4, 9) 2 (1, 2) 6 (4, 7) 0 (0, 0) 0 (0, 0)
HRD+ TC1 post_p 0.86 (0.86, 0.86) NA (NA, NA) 0.79 (0.76, 0.82) 0.54 (0.52, 0.56) 0.53 (0.53, 0.53) 0.58 (0.52, 0.63) NA (NA, NA) NA (NA, NA)
HRD+ TC1 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
HRD+ TC1 rate 0.013 (0.012, 0.015) NA (NA, NA) 0.015 (0.012, 0.018) 0.009 (0.002, 0.016) 0.018 (0.004, 0.032) 0.018 (0.015, 0.022) NA (NA, NA) NA (NA, NA)
HRD+ TC2 count 38 38 38 38 38 38 38 38
HRD+ TC2 time 52 (43, 58) 52 (43, 58) 52 (43, 58) 52 (43, 58) 52 (43, 58) 52 (43, 58) 52 (43, 58) 52 (43, 58)
HRD+ TC2 n 27 (20, 36) 0 (0, 0) 18 (11, 24) 3 (1, 6) 0 (0, 1) 4 (1, 8) 0 (0, 0) 0 (0, 0)
HRD+ TC2 post_p 0.82 (0.72, 0.92) NA (NA, NA) 0.81 (0.71, 0.95) 0.56 (0.51, 0.68) 0.53 (0.5, 0.56) 0.57 (0.51, 0.7) NA (NA, NA) NA (NA, NA)
HRD+ TC2 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
HRD+ TC2 rate 0.015 (0.009, 0.018) NA (NA, NA) 0.008 (0.003, 0.013) 0 (0, 0.019) 0 (0, 0.041) 0.014 (0, 0.026) NA (NA, NA) 0 (0, 0)
HRD+ TC3 count 11 11 11 11 11 11 11 11
HRD+ TC3 time 49 (42, 57) 49 (42, 57) 49 (42, 57) 49 (42, 57) 49 (42, 57) 49 (42, 57) 49 (42, 57) 49 (42, 57)
HRD+ TC3 n 25 (17, 36) 0 (0, 0) 18 (14, 27) 3 (2, 9) 1 (0, 1) 5 (2, 8) 0 (0, 0) 0 (0, 0)
HRD+ TC3 post_p 0.85 (0.75, 0.96) NA (NA, NA) 0.75 (0.71, 0.82) 0.58 (0.52, 0.68) 0.59 (0.58, 0.6) 0.57 (0.52, 0.76) NA (NA, NA) NA (NA, NA)
HRD+ TC3 r_prob 0.5 (0.5, 0.5) 0.33 (0.33, 0.33) 0.5 (0.5, 0.5) 0.33 (0.33, 0.33) 0.5 (0.5, 0.5) 0.33 (0.33, 0.33) 0.5 (0.5, 0.5) 0.33 (0.33, 0.33)
HRD+ TC3 rate 0.014 (0.009, 0.018) NA (NA, NA) 0.013 (0.01, 0.015) 0.013 (0, 0.02) 0.02 (0, 0.066) 0.011 (0.008, 0.023) NA (NA, NA) NA (NA, NA)
HRD+ TC4 count 13 13 13 13 13 13 13 13
HRD+ TC4 time 54 (42, 60) 54 (42, 60) 54 (42, 60) 54 (42, 60) 54 (42, 60) 54 (42, 60) 54 (42, 60) 54 (42, 60)
HRD+ TC4 n 25 (19, 36) 0 (0, 0) 18 (10, 27) 5 (3, 8) 0 (0, 1) 6 (3, 8) 0 (0, 0) 0 (0, 0)
HRD+ TC4 post_p 0.77 (0.73, 0.9) NA (NA, NA) 0.8 (0.71, 0.92) 0.59 (0.54, 0.67) 0.55 (0.53, 0.56) 0.58 (0.52, 0.86) NA (NA, NA) NA (NA, NA)
HRD+ TC4 r_prob 0 (0, 0) 0.33 (0.33, 0.33) 0 (0, 0) 0.33 (0.33, 0.33) 0 (0, 0) 0.33 (0.33, 0.33) 0 (0, 0) 0.33 (0.33, 0.33)
HRD+ TC4 rate 0.015 (0.009, 0.023) NA (NA, NA) 0.01 (0.006, 0.015) 0.013 (0, 0.024) 0 (0, 0.02) 0.009 (0, 0.035) NA (NA, NA) NA (NA, NA)
TP53+ TC1 count 4 4 4 4 4 4 4 4
TP53+ TC1 time 25 (23, 27) 25 (23, 27) 25 (23, 27) 25 (23, 27) 25 (23, 27) 25 (23, 27) 25 (23, 27) 25 (23, 27)
TP53+ TC1 n 23 (22, 25) 10 (7, 11) 10 (8, 14) 7 (5, 10) 1 (0, 2) 0 (0, 1) 0 (0, 0) 0 (0, 0)
TP53+ TC1 post_p 0.84 (0.75, 0.93) 0.69 (0.63, 0.74) 0.61 (0.54, 0.69) 0.55 (0.53, 0.58) 0.51 (0.51, 0.51) 0.51 (0.51, 0.51) NA (NA, NA) NA (NA, NA)
TP53+ TC1 r_prob 0.18 (0.18, 0.18) 0.07 (0.07, 0.07) 0.12 (0.12, 0.12) 0.06 (0.06, 0.06) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TP53+ TC1 rate 0.005 (0.001, 0.007) 0.003 (0, 0.012) 0.004 (0, 0.009) 0.004 (0, 0.013) 0 (0, 0.149) 0 (0, 0) NA (NA, NA) NA (NA, NA)
TP53+ TC2 count 68 68 68 68 68 68 68 68
TP53+ TC2 time 42 (28, 55) 42 (28, 55) 42 (28, 55) 42 (28, 55) 42 (28, 55) 42 (28, 55) 42 (28, 55) 42 (28, 55)
TP53+ TC2 n 36 (23, 56) 20 (10, 35) 22 (11, 36) 14 (7, 26) 0 (0, 1) 3 (1, 6) 0 (0, 0) 0 (0, 0)
TP53+ TC2 post_p 0.82 (0.72, 0.95) 0.75 (0.66, 0.9) 0.81 (0.7, 0.97) 0.78 (0.56, 0.96) 0.52 (0.51, 0.53) 0.55 (0.51, 0.64) NA (NA, NA) NA (NA, NA)
TP53+ TC2 r_prob 0.41 (0.41, 0.41) 0.27 (0.27, 0.27) 0.41 (0.41, 0.41) 0.25 (0.25, 0.25) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TP53+ TC2 rate 0.015 (0.01, 0.019) 0.013 (0.008, 0.02) 0.008 (0.004, 0.014) 0.008 (0, 0.012) 0 (0, 0.042) 0.009 (0, 0.024) NA (NA, NA) NA (NA, NA)
TP53+ TC3 count 9 9 9 9 9 9 9 9
TP53+ TC3 time 29 (24, 47) 29 (24, 47) 29 (24, 47) 29 (24, 47) 29 (24, 47) 29 (24, 47) 29 (24, 47) 29 (24, 47)
TP53+ TC3 n 23 (17, 31) 17 (9, 32) 10 (7, 18) 8 (6, 18) 0 (0, 1) 4 (0, 6) 0 (0, 0) 0 (0, 0)
TP53+ TC3 post_p 0.81 (0.72, 0.86) 0.77 (0.6, 0.85) 0.68 (0.5, 0.87) 0.57 (0.53, 0.91) 0.54 (0.53, 0.54) 0.59 (0.56, 0.83) NA (NA, NA) NA (NA, NA)
TP53+ TC3 r_prob 0 (0, 0) 0 (0, 0) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.5 (0.5, 0.5) 0.33 (0.33, 0.33) 0.5 (0.5, 0.5) 0.33 (0.33, 0.33)
TP53+ TC3 rate 0.01 (0.004, 0.016) 0.011 (0.004, 0.014) 0.006 (0, 0.014) 0 (0, 0.01) 0 (0, 0.014) 0 (0, 0) NA (NA, NA) NA (NA, NA)
TP53+ TC4 count 9 9 9 9 9 9 9 9
TP53+ TC4 time 35 (26, 47) 35 (26, 47) 35 (26, 47) 35 (26, 47) 35 (26, 47) 35 (26, 47) 35 (26, 47) 35 (26, 47)
TP53+ TC4 n 30 (20, 46) 22 (13, 30) 15 (9, 34) 10 (7, 26) 0 (0, 0) 3 (1, 7) 0 (0, 0) 0 (0, 0)
TP53+ TC4 post_p 0.8 (0.73, 0.9) 0.76 (0.7, 0.84) 0.73 (0.52, 0.87) 0.57 (0.51, 0.78) NA (NA, NA) 0.56 (0.53, 0.76) NA (NA, NA) NA (NA, NA)
TP53+ TC4 r_prob 0 (0, 0) 0.33 (0.33, 0.33) 0 (0, 0) 0.31 (0.31, 0.31) 0 (0, 0) 0.33 (0.33, 0.33) 0 (0, 0) 0.33 (0.33, 0.33)
TP53+ TC4 rate 0.011 (0.004, 0.014) 0.011 (0.008, 0.018) 0.01 (0.006, 0.015) 0.01 (0.005, 0.018) NA (NA, NA) 0 (0, 0.022) NA (NA, NA) NA (NA, NA)
TEfus+ TC2 count 279 279 279 279 279 279 279 279
TEfus+ TC2 time 38 (26, 55) 38 (26, 55) 38 (26, 55) 38 (26, 55) 38 (26, 55) 38 (26, 55) 38 (26, 55) 38 (26, 55)
TEfus+ TC2 n 6 (3, 11) 31 (17, 52) 22 (13, 40) 16 (7, 29) 10 (5, 20) 2 (0, 5) 0 (0, 0) 0 (0, 0)
TEfus+ TC2 post_p 0.58 (0.51, 0.76) 0.86 (0.72, 0.99) 0.78 (0.7, 0.97) 0.74 (0.55, 0.94) 0.71 (0.53, 0.91) 0.54 (0.51, 0.66) 0.57 (0.57, 0.57) NA (NA, NA)
TEfus+ TC2 r_prob 0.41 (0.41, 0.41) 0.27 (0.27, 0.27) 0.41 (0.41, 0.41) 0.25 (0.25, 0.25) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TEfus+ TC2 rate 0.006 (0, 0.018) 0.009 (0.003, 0.013) 0.009 (0.003, 0.014) 0.008 (0, 0.013) 0.007 (0, 0.016) 0 (0, 0.018) 0 (0, 0) 0 (0, 0)
TEfus+ TC3 count 1 1 1 1 1 1 1 1
TEfus+ TC3 time 34 (34, 34) 34 (34, 34) 34 (34, 34) 34 (34, 34) 34 (34, 34) 34 (34, 34) 34 (34, 34) 34 (34, 34)
TEfus+ TC3 n 4 (4, 4) 9 (9, 9) 8 (8, 8) 18 (18, 18) 9 (9, 9) 4 (4, 4) 0 (0, 0) 0 (0, 0)
TEfus+ TC3 post_p 0.6 (0.6, 0.6) 0.83 (0.83, 0.83) 0.55 (0.55, 0.55) 0.77 (0.77, 0.77) 0.52 (0.52, 0.52) 0.52 (0.52, 0.52) NA (NA, NA) NA (NA, NA)
TEfus+ TC3 r_prob 0 (0, 0) 0 (0, 0) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.5 (0.5, 0.5) 0.33 (0.33, 0.33) 0.5 (0.5, 0.5) 0.33 (0.33, 0.33)
TEfus+ TC3 rate 0.016 (0.016, 0.016) 0 (0, 0) 0.008 (0.008, 0.008) 0 (0, 0) 0.018 (0.018, 0.018) 0.012 (0.012, 0.012) NA (NA, NA) NA (NA, NA)
TEfus+ TC4 count 3 3 3 3 3 3 3 3
TEfus+ TC4 time 29 (25, 35) 29 (25, 35) 29 (25, 35) 29 (25, 35) 29 (25, 35) 29 (25, 35) 29 (25, 35) 29 (25, 35)
TEfus+ TC4 n 6 (4, 7) 23 (21, 29) 14 (10, 14) 9 (7, 9) 3 (2, 10) 4 (1, 5) 0 (0, 0) 0 (0, 0)
TEfus+ TC4 post_p 0.6 (0.53, 0.63) 0.76 (0.75, 0.78) 0.72 (0.66, 0.74) 0.68 (0.58, 0.88) 0.57 (0.54, 0.84) 0.58 (0.53, 0.63) NA (NA, NA) NA (NA, NA)
TEfus+ TC4 r_prob 0 (0, 0) 0.33 (0.33, 0.33) 0 (0, 0) 0.31 (0.31, 0.31) 0 (0, 0) 0.33 (0.33, 0.33) 0 (0, 0) 0.33 (0.33, 0.33)
TEfus+ TC4 rate 0 (0, 0.012) 0.01 (0.006, 0.011) 0.005 (0.001, 0.011) 0 (0, 0.011) 0 (0, 0.004) 0 (0, 0) NA (NA, NA) NA (NA, NA)
PI3K+ TC1 count 1 1 1 1 1 1 1 1
PI3K+ TC1 time 35 (35, 35) 35 (35, 35) 35 (35, 35) 35 (35, 35) 35 (35, 35) 35 (35, 35) 35 (35, 35) 35 (35, 35)
PI3K+ TC1 n 12 (12, 12) 27 (27, 27) 16 (16, 16) 18 (18, 18) 0 (0, 0) 0 (0, 0) 1 (1, 1) 0 (0, 0)
PI3K+ TC1 post_p 0.75 (0.75, 0.75) 0.76 (0.76, 0.76) 0.72 (0.72, 0.72) 0.75 (0.75, 0.75) NA (NA, NA) NA (NA, NA) 0.52 (0.52, 0.52) NA (NA, NA)
PI3K+ TC1 r_prob 0.27 (0.27, 0.27) 0.07 (0.07, 0.07) 0.07 (0.07, 0.07) 0.06 (0.06, 0.06) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
PI3K+ TC1 rate 0.011 (0.011, 0.011) 0.01 (0.01, 0.01) 0.016 (0.016, 0.016) 0.007 (0.007, 0.007) NA (NA, NA) NA (NA, NA) 0 (0, 0) NA (NA, NA)
PI3K+ TC2 count 77 77 77 77 77 77 77 77
PI3K+ TC2 time 41 (28, 56) 41 (28, 56) 41 (28, 56) 41 (28, 56) 41 (28, 56) 41 (28, 56) 41 (28, 56) 41 (28, 56)
PI3K+ TC2 n 17 (8, 30) 30 (16, 44) 20 (10, 41) 14 (7, 25) 0 (0, 0) 2 (0, 4) 2 (1, 6) 0 (0, 0)
PI3K+ TC2 post_p 0.75 (0.53, 0.9) 0.87 (0.73, 0.99) 0.76 (0.59, 0.9) 0.79 (0.54, 0.92) NA (NA, NA) 0.54 (0.51, 0.61) 0.55 (0.5, 0.64) NA (NA, NA)
PI3K+ TC2 r_prob 0.07 (0.07, 0.07) 0.27 (0.27, 0.27) 0.27 (0.27, 0.27) 0.25 (0.25, 0.25) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
PI3K+ TC2 rate 0.014 (0.005, 0.024) 0.008 (0.005, 0.013) 0.015 (0.006, 0.022) 0.008 (0, 0.013) NA (NA, NA) 0 (0, 0.019) 0 (0, 0.027) NA (NA, NA)
PI3K+ TC3 count 7 7 7 7 7 7 7 7
PI3K+ TC3 time 33 (31, 42) 33 (31, 42) 33 (31, 42) 33 (31, 42) 33 (31, 42) 33 (31, 42) 33 (31, 42) 33 (31, 42)
PI3K+ TC3 n 16 (8, 24) 18 (8, 26) 15 (8, 22) 9 (6, 16) 0 (0, 0) 2 (1, 4) 3 (1, 4) 0 (0, 0)
PI3K+ TC3 post_p 0.73 (0.57, 0.83) 0.75 (0.64, 0.84) 0.78 (0.53, 0.84) 0.76 (0.51, 0.89) NA (NA, NA) 0.52 (0.51, 0.53) 0.55 (0.51, 0.76) NA (NA, NA)
PI3K+ TC3 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
PI3K+ TC3 rate 0.017 (0.008, 0.019) 0.012 (0.003, 0.017) 0.012 (0.005, 0.019) 0.011 (0, 0.015) NA (NA, NA) 0 (0, 0.026) 0 (0, 0.01) NA (NA, NA)
PI3K+ TC4 count 4 4 4 4 4 4 4 4
PI3K+ TC4 time 28 (23, 49) 28 (23, 49) 28 (23, 49) 28 (23, 49) 28 (23, 49) 28 (23, 49) 28 (23, 49) 28 (23, 49)
PI3K+ TC4 n 8 (7, 37) 23 (20, 38) 12 (10, 41) 12 (7, 32) 0 (0, 0) 5 (3, 7) 4 (3, 6) 0 (0, 0)
PI3K+ TC4 post_p 0.71 (0.56, 0.82) 0.74 (0.72, 0.84) 0.62 (0.52, 0.79) 0.65 (0.59, 0.72) NA (NA, NA) 0.56 (0.52, 0.6) 0.61 (0.57, 0.71) NA (NA, NA)
PI3K+ TC4 r_prob 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.31 (0.31, 0.31) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
PI3K+ TC4 rate 0.012 (0.003, 0.015) 0.004 (0.001, 0.008) 0.017 (0.015, 0.023) 0.003 (0, 0.014) NA (NA, NA) 0.011 (0.003, 0.034) 0 (0, 0.016) NA (NA, NA)
Futility:
signature treatment var —- —+ –+- –++ -+– -+-+ -++- -+++ +— +–+ +-+- +-++ ++– ++-+ +++- ++++
all TC1 count 49 49 49 49 49 49 49 49 49 49 49 49 49 49 49 49
all TC1 time 46 (21, 58) 46 (21, 58) 46 (21, 58) 46 (21, 58) 46 (21, 58) 46 (21, 58) 46 (21, 58) 46 (21, 58) 46 (21, 58) 46 (21, 58) 46 (21, 58) 46 (21, 58) 46 (21, 58) 46 (21, 58) 46 (21, 58) 46 (21, 58)
all TC1 n 41 (23, 83) 12 (7, 19) 5 (1, 9) 13 (8, 24) 20 (11, 38) 11 (5, 26) 11 (5, 20) 9 (3, 20) 10 (5, 20) 0 (0, 0) 7 (3, 13) 2 (0, 4) 0 (0, 1) 3 (0, 5) 0 (0, 0) 0 (0, 0)
all TC1 post_p 0.22 (0.04, 0.44) 0.3 (0.1, 0.46) 0.4 (0.29, 0.49) 0.2 (0.02, 0.43) 0.29 (0.12, 0.47) 0.35 (0.09, 0.48) 0.28 (0.07, 0.48) 0.36 (0.07, 0.47) 0.37 (0.14, 0.49) NA (NA, NA) 0.29 (0.07, 0.46) 0.44 (0.31, 0.49) 0.46 (0.37, 0.47) 0.45 (0.33, 0.49) NA (NA, NA) NA (NA, NA)
all TC1 r_prob 0.37 (0.37, 0.37) 0.27 (0.27, 0.27) 0.18 (0.18, 0.18) 0.07 (0.07, 0.07) 0.18 (0.18, 0.18) 0.07 (0.07, 0.07) 0.12 (0.12, 0.12) 0.06 (0.06, 0.06) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
all TC1 rate 0.027 (0.021, 0.038) 0.032 (0.02, 0.049) 0.026 (0.01, 0.051) 0.029 (0.02, 0.043) 0.028 (0.021, 0.037) 0.029 (0.019, 0.047) 0.025 (0.018, 0.048) 0.024 (0.017, 0.053) 0.028 (0.017, 0.043) NA (NA, NA) 0.033 (0.019, 0.068) 0.029 (0, 0.086) 0.03 (0, 0.116) 0.031 (0.021, 0.069) NA (NA, NA) 0 (0, 0)
all TC3 count 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3
all TC3 time 58 (48, 59) 58 (48, 59) 58 (48, 59) 58 (48, 59) 58 (48, 59) 58 (48, 59) 58 (48, 59) 58 (48, 59) 58 (48, 59) 58 (48, 59) 58 (48, 59) 58 (48, 59) 58 (48, 59) 58 (48, 59) 58 (48, 59) 58 (48, 59)
all TC3 n 48 (35, 84) 14 (12, 28) 3 (1, 5) 15 (12, 21) 15 (9, 38) 19 (12, 25) 15 (12, 19) 15 (13, 18) 17 (15, 19) 0 (0, 0) 6 (6, 9) 2 (0, 3) 2 (0, 3) 4 (2, 5) 0 (0, 0) 0 (0, 1)
all TC3 post_p 0.19 (0.17, 0.35) 0.36 (0.32, 0.45) 0.41 (0.36, 0.44) 0.09 (0.06, 0.18) 0.2 (0.13, 0.26) 0.32 (0.21, 0.32) 0.11 (0.05, 0.24) 0.45 (0.19, 0.45) 0.31 (0.17, 0.4) NA (NA, NA) 0.2 (0.09, 0.41) 0.47 (0.45, 0.48) 0.49 (0.49, 0.49) 0.46 (0.38, 0.48) NA (NA, NA) NA (NA, NA)
all TC3 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.5 (0.5, 0.5) 0.33 (0.33, 0.33) 0.5 (0.5, 0.5) 0.33 (0.33, 0.33) 0.5 (0.5, 0.5) 0.33 (0.33, 0.33) 0.5 (0.5, 0.5) 0.33 (0.33, 0.33)
all TC3 rate 0.024 (0.023, 0.027) 0.023 (0.021, 0.025) 0.027 (0.02, 0.029) 0.034 (0.023, 0.035) 0.034 (0.026, 0.035) 0.027 (0.023, 0.031) 0.024 (0.019, 0.033) 0.014 (0.013, 0.026) 0.022 (0.022, 0.026) NA (NA, NA) 0.024 (0.021, 0.04) 0.05 (0.031, 0.069) 0.011 (0.01, 0.013) 0.027 (0.022, 0.077) NA (NA, NA) 0.231 (0.231, 0.231)
all TC4 count 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3
all TC4 time 30 (13, 45) 30 (13, 45) 30 (13, 45) 30 (13, 45) 30 (13, 45) 30 (13, 45) 30 (13, 45) 30 (13, 45) 30 (13, 45) 30 (13, 45) 30 (13, 45) 30 (13, 45) 30 (13, 45) 30 (13, 45) 30 (13, 45) 30 (13, 45)
all TC4 n 21 (16, 22) 9 (6, 13) 4 (2, 4) 16 (11, 17) 16 (8, 24) 11 (9, 13) 9 (3, 11) 10 (7, 11) 6 (3, 18) 0 (0, 0) 6 (1, 8) 2 (0, 4) 0 (0, 0) 2 (0, 6) 0 (0, 0) 0 (0, 0)
all TC4 post_p 0.32 (0.1, 0.4) 0.31 (0.19, 0.44) 0.46 (0.45, 0.47) 0.42 (0.17, 0.43) 0.3 (0.25, 0.44) 0.41 (0.38, 0.43) 0.37 (0.19, 0.47) 0.42 (0.34, 0.43) 0.38 (0.24, 0.46) NA (NA, NA) 0.21 (0.14, 0.29) 0.49 (0.49, 0.49) NA (NA, NA) 0.29 (0.21, 0.37) NA (NA, NA) NA (NA, NA)
all TC4 r_prob 0 (0, 0) 0.33 (0.33, 0.33) 0 (0, 0) 0.33 (0.33, 0.33) 0 (0, 0) 0.33 (0.33, 0.33) 0 (0, 0) 0.31 (0.31, 0.31) 0 (0, 0) 0.33 (0.33, 0.33) 0 (0, 0) 0.33 (0.33, 0.33) 0 (0, 0) 0.33 (0.33, 0.33) 0 (0, 0) 0.33 (0.33, 0.33)
all TC4 rate 0.029 (0.023, 0.03) 0.034 (0.007, 0.037) 0.015 (0.003, 0.022) 0.018 (0.014, 0.022) 0.027 (0.022, 0.087) 0.019 (0.019, 0.028) 0.025 (0.005, 0.034) 0.02 (0.017, 0.027) 0.02 (0.004, 0.071) NA (NA, NA) 0.038 (0.035, 0.041) 0.027 (0.018, 0.035) NA (NA, NA) 0.03 (0.029, 0.03) NA (NA, NA) NA (NA, NA)
HRD+ TC1 count 10 10 10 10 10 10 10 10
HRD+ TC1 time 57 (56, 60) 57 (56, 60) 57 (56, 60) 57 (56, 60) 57 (56, 60) 57 (56, 60) 57 (56, 60) 57 (56, 60)
HRD+ TC1 n 28 (15, 40) 0 (0, 0) 16 (10, 27) 4 (3, 7) 1 (0, 3) 4 (3, 7) 0 (0, 0) 0 (0, 0)
HRD+ TC1 post_p 0.3 (0.09, 0.47) NA (NA, NA) 0.23 (0.05, 0.44) 0.43 (0.37, 0.48) 0.45 (0.45, 0.46) 0.28 (0.17, 0.39) NA (NA, NA) NA (NA, NA)
HRD+ TC1 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
HRD+ TC1 rate 0.026 (0.02, 0.037) NA (NA, NA) 0.025 (0.02, 0.045) 0.031 (0.02, 0.042) 0.024 (0, 0.054) 0.038 (0.028, 0.072) NA (NA, NA) NA (NA, NA)
HRD+ TC2 count 1 1 1 1 1 1 1 1
HRD+ TC2 time 58 (58, 58) 58 (58, 58) 58 (58, 58) 58 (58, 58) 58 (58, 58) 58 (58, 58) 58 (58, 58) 58 (58, 58)
HRD+ TC2 n 13 (13, 13) 0 (0, 0) 43 (43, 43) 3 (3, 3) 0 (0, 0) 2 (2, 2) 0 (0, 0) 0 (0, 0)
HRD+ TC2 post_p 0.16 (0.16, 0.16) NA (NA, NA) 0.35 (0.35, 0.35) 0.49 (0.49, 0.49) NA (NA, NA) 0.47 (0.47, 0.47) NA (NA, NA) NA (NA, NA)
HRD+ TC2 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
HRD+ TC2 rate 0.027 (0.027, 0.027) NA (NA, NA) 0.015 (0.015, 0.015) 0.028 (0.028, 0.028) NA (NA, NA) 0.015 (0.015, 0.015) NA (NA, NA) NA (NA, NA)
HRD+ TC3 count 16 16 16 16 16 16 16 16
HRD+ TC3 time 54 (42, 59) 54 (42, 59) 54 (42, 59) 54 (42, 59) 54 (42, 59) 54 (42, 59) 54 (42, 59) 54 (42, 59)
HRD+ TC3 n 27 (18, 34) 0 (0, 0) 19 (10, 24) 4 (2, 7) 1 (0, 2) 4 (0, 8) 0 (0, 0) 0 (0, 0)
HRD+ TC3 post_p 0.38 (0.19, 0.46) NA (NA, NA) 0.3 (0.11, 0.46) 0.48 (0.35, 0.49) 0.46 (0.45, 0.48) 0.4 (0.18, 0.48) NA (NA, NA) NA (NA, NA)
HRD+ TC3 r_prob 0.5 (0.5, 0.5) 0.33 (0.33, 0.33) 0.5 (0.5, 0.5) 0.33 (0.33, 0.33) 0.5 (0.5, 0.5) 0.33 (0.33, 0.33) 0.5 (0.5, 0.5) 0.33 (0.33, 0.33)
HRD+ TC3 rate 0.024 (0.022, 0.027) NA (NA, NA) 0.027 (0.015, 0.039) 0.024 (0.018, 0.036) 0.022 (0, 0.074) 0.03 (0.022, 0.051) NA (NA, NA) 0.095 (0.032, 0.158)
HRD+ TC4 count 11 11 11 11 11 11 11 11
HRD+ TC4 time 57 (53, 58) 57 (53, 58) 57 (53, 58) 57 (53, 58) 57 (53, 58) 57 (53, 58) 57 (53, 58) 57 (53, 58)
HRD+ TC4 n 26 (18, 30) 0 (0, 0) 25 (14, 28) 5 (4, 9) 0 (0, 1) 3 (2, 6) 0 (0, 0) 0 (0, 0)
HRD+ TC4 post_p 0.42 (0.31, 0.48) NA (NA, NA) 0.33 (0.18, 0.42) 0.43 (0.39, 0.5) 0.49 (0.48, 0.49) 0.41 (0.23, 0.49) NA (NA, NA) NA (NA, NA)
HRD+ TC4 r_prob 0 (0, 0) 0.33 (0.33, 0.33) 0 (0, 0) 0.33 (0.33, 0.33) 0 (0, 0) 0.33 (0.33, 0.33) 0 (0, 0) 0.33 (0.33, 0.33)
HRD+ TC4 rate 0.022 (0.016, 0.029) NA (NA, NA) 0.02 (0.016, 0.028) 0.022 (0.016, 0.029) 0 (0, 0.06) 0.047 (0.019, 0.07) NA (NA, NA) NA (NA, NA)
TP53+ TC1 count 185 185 185 185 185 185 185 185
TP53+ TC1 time 41 (29, 56) 41 (29, 56) 41 (29, 56) 41 (29, 56) 41 (29, 56) 41 (29, 56) 41 (29, 56) 41 (29, 56)
TP53+ TC1 n 22 (13, 46) 15 (8, 30) 13 (7, 26) 11 (5, 24) 0 (0, 1) 3 (1, 6) 0 (0, 0) 0 (0, 0)
TP53+ TC1 post_p 0.32 (0.11, 0.48) 0.32 (0.12, 0.47) 0.31 (0.08, 0.47) 0.35 (0.12, 0.48) 0.47 (0.44, 0.49) 0.44 (0.32, 0.5) NA (NA, NA) 0.44 (0.44, 0.44)
TP53+ TC1 r_prob 0.18 (0.18, 0.18) 0.07 (0.07, 0.07) 0.12 (0.12, 0.12) 0.06 (0.06, 0.06) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TP53+ TC1 rate 0.026 (0.019, 0.035) 0.027 (0.019, 0.044) 0.025 (0.017, 0.04) 0.024 (0.016, 0.044) 0.024 (0, 0.129) 0.033 (0.016, 0.089) NA (NA, NA) 0.024 (0, 0.118)
TP53+ TC2 count 10 10 10 10 10 10 10 10
TP53+ TC2 time 24 (22, 41) 24 (22, 41) 24 (22, 41) 24 (22, 41) 24 (22, 41) 24 (22, 41) 24 (22, 41) 24 (22, 41)
TP53+ TC2 n 21 (13, 34) 16 (9, 25) 14 (10, 17) 11 (7, 16) 0 (0, 0) 2 (0, 4) 0 (0, 0) 0 (0, 0)
TP53+ TC2 post_p 0.38 (0.27, 0.47) 0.41 (0.29, 0.49) 0.39 (0.27, 0.45) 0.47 (0.38, 0.49) NA (NA, NA) 0.47 (0.36, 0.49) NA (NA, NA) NA (NA, NA)
TP53+ TC2 r_prob 0.41 (0.41, 0.41) 0.27 (0.27, 0.27) 0.41 (0.41, 0.41) 0.25 (0.25, 0.25) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TP53+ TC2 rate 0.023 (0.018, 0.032) 0.021 (0.015, 0.029) 0.017 (0.013, 0.03) 0.019 (0.012, 0.021) NA (NA, NA) 0.012 (0, 0.061) NA (NA, NA) NA (NA, NA)
TP53+ TC3 count 86 86 86 86 86 86 86 86
TP53+ TC3 time 41 (30, 56) 41 (30, 56) 41 (30, 56) 41 (30, 56) 41 (30, 56) 41 (30, 56) 41 (30, 56) 41 (30, 56)
TP53+ TC3 n 22 (12, 44) 16 (8, 34) 14 (10, 26) 11 (6, 22) 0 (0, 2) 4 (1, 7) 0 (0, 0) 0 (0, 0)
TP53+ TC3 post_p 0.36 (0.14, 0.48) 0.34 (0.12, 0.48) 0.32 (0.15, 0.46) 0.36 (0.15, 0.48) 0.48 (0.42, 0.49) 0.44 (0.34, 0.49) NA (NA, NA) NA (NA, NA)
TP53+ TC3 r_prob 0 (0, 0) 0 (0, 0) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.5 (0.5, 0.5) 0.33 (0.33, 0.33) 0.5 (0.5, 0.5) 0.33 (0.33, 0.33)
TP53+ TC3 rate 0.024 (0.017, 0.034) 0.026 (0.019, 0.041) 0.022 (0.017, 0.034) 0.022 (0.016, 0.042) 0.019 (0, 0.078) 0.028 (0.012, 0.071) 0 (0, 0) 0.115 (0.023, 0.208)
TP53+ TC4 count 77 77 77 77 77 77 77 77
TP53+ TC4 time 35 (25, 53) 35 (25, 53) 35 (25, 53) 35 (25, 53) 35 (25, 53) 35 (25, 53) 35 (25, 53) 35 (25, 53)
TP53+ TC4 n 19 (11, 35) 15 (8, 27) 12 (5, 23) 11 (7, 16) 0 (0, 1) 3 (1, 6) 0 (0, 0) 0 (0, 0)
TP53+ TC4 post_p 0.35 (0.16, 0.48) 0.35 (0.15, 0.47) 0.37 (0.16, 0.48) 0.38 (0.16, 0.48) 0.47 (0.42, 0.5) 0.45 (0.34, 0.49) NA (NA, NA) NA (NA, NA)
TP53+ TC4 r_prob 0 (0, 0) 0.33 (0.33, 0.33) 0 (0, 0) 0.31 (0.31, 0.31) 0 (0, 0) 0.33 (0.33, 0.33) 0 (0, 0) 0.33 (0.33, 0.33)
TP53+ TC4 rate 0.025 (0.018, 0.036) 0.027 (0.019, 0.039) 0.024 (0.016, 0.039) 0.023 (0.014, 0.042) 0.048 (0, 0.156) 0.029 (0, 0.066) NA (NA, NA) 0 (0, 0)
TEfus+ TC1 count 219 219 219 219 219 219 219 219
TEfus+ TC1 time 45 (33, 56) 45 (33, 56) 45 (33, 56) 45 (33, 56) 45 (33, 56) 45 (33, 56) 45 (33, 56) 45 (33, 56)
TEfus+ TC1 n 5 (3, 10) 17 (9, 33) 13 (7, 26) 12 (6, 24) 9 (5, 16) 3 (1, 6) 0 (0, 0) 0 (0, 0)
TEfus+ TC1 post_p 0.42 (0.22, 0.49) 0.24 (0.06, 0.46) 0.29 (0.07, 0.47) 0.3 (0.09, 0.46) 0.33 (0.11, 0.47) 0.45 (0.35, 0.5) NA (NA, NA) 0.5 (0.5, 0.5)
TEfus+ TC1 r_prob 0.18 (0.18, 0.18) 0.07 (0.07, 0.07) 0.12 (0.12, 0.12) 0.06 (0.06, 0.06) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TEfus+ TC1 rate 0.028 (0.014, 0.055) 0.025 (0.017, 0.039) 0.026 (0.018, 0.04) 0.024 (0.017, 0.04) 0.027 (0.017, 0.052) 0.033 (0.012, 0.074) NA (NA, NA) 0 (0, 0.024)
TEfus+ TC3 count 142 142 142 142 142 142 142 142
TEfus+ TC3 time 44 (32, 57) 44 (32, 57) 44 (32, 57) 44 (32, 57) 44 (32, 57) 44 (32, 57) 44 (32, 57) 44 (32, 57)
TEfus+ TC3 n 5 (2, 10) 18 (10, 39) 14 (7, 25) 11 (6, 20) 10 (6, 18) 3 (1, 6) 0 (0, 0) 0 (0, 0)
TEfus+ TC3 post_p 0.43 (0.29, 0.48) 0.31 (0.07, 0.48) 0.31 (0.1, 0.46) 0.37 (0.12, 0.48) 0.31 (0.14, 0.47) 0.44 (0.35, 0.49) NA (NA, NA) 0.45 (0.45, 0.45)
TEfus+ TC3 r_prob 0 (0, 0) 0 (0, 0) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.5 (0.5, 0.5) 0.33 (0.33, 0.33) 0.5 (0.5, 0.5) 0.33 (0.33, 0.33)
TEfus+ TC3 rate 0.028 (0.016, 0.06) 0.022 (0.015, 0.038) 0.022 (0.016, 0.041) 0.022 (0.016, 0.04) 0.025 (0.016, 0.039) 0.029 (0.012, 0.057) NA (NA, NA) 0.043 (0.009, 0.193)
TEfus+ TC4 count 121 121 121 121 121 121 121 121
TEfus+ TC4 time 44 (32, 56) 44 (32, 56) 44 (32, 56) 44 (32, 56) 44 (32, 56) 44 (32, 56) 44 (32, 56) 44 (32, 56)
TEfus+ TC4 n 5 (3, 9) 20 (10, 43) 14 (8, 28) 12 (7, 23) 9 (5, 16) 3 (1, 6) 0 (0, 0) 0 (0, 0)
TEfus+ TC4 post_p 0.43 (0.25, 0.49) 0.29 (0.06, 0.46) 0.3 (0.12, 0.47) 0.35 (0.11, 0.47) 0.35 (0.12, 0.49) 0.46 (0.38, 0.5) 0.43 (0.43, 0.43) NA (NA, NA)
TEfus+ TC4 r_prob 0 (0, 0) 0.33 (0.33, 0.33) 0 (0, 0) 0.31 (0.31, 0.31) 0 (0, 0) 0.33 (0.33, 0.33) 0 (0, 0) 0.33 (0.33, 0.33)
TEfus+ TC4 rate 0.028 (0.014, 0.064) 0.023 (0.017, 0.034) 0.024 (0.017, 0.038) 0.022 (0.016, 0.04) 0.025 (0.014, 0.046) 0.026 (0, 0.08) 0.037 (0.037, 0.037) 0.032 (0.032, 0.032)
PI3K+ TC1 count 160 160 160 160 160 160 160 160
PI3K+ TC1 time 44 (30, 55) 44 (30, 55) 44 (30, 55) 44 (30, 55) 44 (30, 55) 44 (30, 55) 44 (30, 55) 44 (30, 55)
PI3K+ TC1 n 14 (8, 25) 16 (9, 32) 15 (8, 31) 12 (6, 24) 0 (0, 0) 3 (1, 5) 3 (0, 6) 0 (0, 0)
PI3K+ TC1 post_p 0.33 (0.1, 0.47) 0.23 (0.06, 0.46) 0.35 (0.07, 0.47) 0.34 (0.1, 0.48) NA (NA, NA) 0.45 (0.34, 0.49) 0.44 (0.26, 0.49) NA (NA, NA)
PI3K+ TC1 r_prob 0.27 (0.27, 0.27) 0.07 (0.07, 0.07) 0.07 (0.07, 0.07) 0.06 (0.06, 0.06) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
PI3K+ TC1 rate 0.027 (0.019, 0.043) 0.025 (0.017, 0.04) 0.028 (0.019, 0.044) 0.024 (0.016, 0.048) NA (NA, NA) 0.032 (0.015, 0.081) 0.033 (0.02, 0.096) 0 (0, 0)
PI3K+ TC3 count 70 70 70 70 70 70 70 70
PI3K+ TC3 time 41 (30, 54) 41 (30, 54) 41 (30, 54) 41 (30, 54) 41 (30, 54) 41 (30, 54) 41 (30, 54) 41 (30, 54)
PI3K+ TC3 n 12 (7, 19) 18 (10, 36) 17 (9, 32) 10 (5, 16) 0 (0, 0) 3 (1, 5) 3 (1, 6) 0 (0, 0)
PI3K+ TC3 post_p 0.36 (0.15, 0.49) 0.31 (0.09, 0.49) 0.37 (0.15, 0.48) 0.37 (0.16, 0.48) NA (NA, NA) 0.46 (0.38, 0.5) 0.44 (0.31, 0.49) NA (NA, NA)
PI3K+ TC3 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
PI3K+ TC3 rate 0.027 (0.018, 0.046) 0.022 (0.016, 0.033) 0.024 (0.019, 0.037) 0.023 (0.015, 0.041) NA (NA, NA) 0.028 (0, 0.067) 0.033 (0.012, 0.082) 0.231 (0.231, 0.231)
PI3K+ TC4 count 91 91 91 91 91 91 91 91
PI3K+ TC4 time 35 (24, 53) 35 (24, 53) 35 (24, 53) 35 (24, 53) 35 (24, 53) 35 (24, 53) 35 (24, 53) 35 (24, 53)
PI3K+ TC4 n 13 (8, 22) 17 (11, 31) 14 (9, 26) 11 (7, 22) 0 (0, 0) 2 (0, 6) 3 (1, 6) 0 (0, 0)
PI3K+ TC4 post_p 0.36 (0.17, 0.48) 0.34 (0.12, 0.48) 0.34 (0.14, 0.48) 0.38 (0.18, 0.48) NA (NA, NA) 0.45 (0.36, 0.49) 0.45 (0.36, 0.49) NA (NA, NA)
PI3K+ TC4 r_prob 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.31 (0.31, 0.31) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
PI3K+ TC4 rate 0.027 (0.017, 0.043) 0.021 (0.015, 0.031) 0.025 (0.018, 0.037) 0.022 (0.015, 0.038) NA (NA, NA) 0.031 (0, 0.106) 0.03 (0.009, 0.068) 0.031 (0.006, 0.031)