Simulation scenario 3, HS phase

Setting description

TC2 more effective in the TEfus+ signatures

Simulations setting

Survival curves (by signature)

PFS distributions (by signature)

Treatment effects (by signature)

signature	var	Other	TC1	TC2	TC3	TC4
all	param	scale = 0.024, shape = 1.3	scale = 0.027, shape = 1.3	scale = 0.02, shape = 1.3	scale = 0.024, shape = 1.3	scale = 0.024, shape = 1.3
all	summary	mean = 39, median = 31.9	mean = 34.3, median = 28	mean = 45.3, median = 37	mean = 39, median = 31.9	mean = 39, median = 31.9
all	effect	af = 1, hr = 1	af = 0.88, hr = 1.18	af = 1.16, hr = 0.83	af = 1, hr = 1	af = 1, hr = 1
HRD+	param	scale = 0.024, shape = 1.3	scale = 0.027, shape = 1.3	scale = 0.02, shape = 1.3	scale = 0.024, shape = 1.3	scale = 0.024, shape = 1.3
HRD+	summary	mean = 39, median = 31.9	mean = 34.3, median = 28	mean = 47.3, median = 38.7	mean = 39, median = 31.9	mean = 39, median = 31.9
HRD+	effect	af = 1, hr = 1	af = 0.88, hr = 1.18	af = 1.21, hr = 0.78	af = 1, hr = 1	af = 1, hr = 1
TP53+	param	scale = 0.024, shape = 1.3	scale = 0.027, shape = 1.3	scale = 0.02, shape = 1.3	scale = 0.024, shape = 1.3	scale = 0.024, shape = 1.3
TP53+	summary	mean = 39, median = 31.9	mean = 34.3, median = 28	mean = 46.4, median = 37.9	mean = 39, median = 31.9	mean = 39, median = 31.9
TP53+	effect	af = 1, hr = 1	af = 0.88, hr = 1.18	af = 1.19, hr = 0.8	af = 1, hr = 1	af = 1, hr = 1
TEfus+	param	scale = 0.024, shape = 1.3	scale = 0.027, shape = 1.3	scale = 0.013, shape = 1.3	scale = 0.024, shape = 1.3	scale = 0.024, shape = 1.3
TEfus+	summary	mean = 39, median = 31.9	mean = 34.3, median = 28	mean = 70.5, median = 57.5	mean = 39, median = 31.9	mean = 39, median = 31.9
TEfus+	effect	af = 1, hr = 1	af = 0.88, hr = 1.18	af = 1.8, hr = 0.46	af = 1, hr = 1	af = 1, hr = 1
PI3K+	param	scale = 0.024, shape = 1.3	scale = 0.027, shape = 1.3	scale = 0.019, shape = 1.3	scale = 0.024, shape = 1.3	scale = 0.024, shape = 1.3
PI3K+	summary	mean = 39, median = 31.9	mean = 34.3, median = 28	mean = 49.8, median = 40.6	mean = 39, median = 31.9	mean = 39, median = 31.9
PI3K+	effect	af = 1, hr = 1	af = 0.88, hr = 1.18	af = 1.27, hr = 0.73	af = 1, hr = 1	af = 1, hr = 1

Survival curves (by subgroup)

PFS distributions (by subgroup)

Treatment effects (by subgroup)

subtype	var	Other	TC1	TC2	TC3	TC4
—-	param	scale = 0.024, shape = 1.3	scale = 0.027, shape = 1.3	scale = 0.024, shape = 1.3	scale = 0.024, shape = 1.3	scale = 0.024, shape = 1.3
—-	summary	mean = 39, median = 31.9	mean = 34.3, median = 28	mean = 39, median = 31.9	mean = 39, median = 31.9	mean = 39, median = 31.9
—-	effect	af = 1, hr = 1	af = 0.88, hr = 1.18	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
—+	param	scale = 0.024, shape = 1.3	scale = 0.027, shape = 1.3	scale = 0.024, shape = 1.3	scale = 0.024, shape = 1.3	scale = 0.024, shape = 1.3
—+	summary	mean = 39, median = 31.9	mean = 34.3, median = 28	mean = 39, median = 31.9	mean = 39, median = 31.9	mean = 39, median = 31.9
—+	effect	af = 1, hr = 1	af = 0.88, hr = 1.18	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
–+-	param	scale = 0.024, shape = 1.3	scale = 0.027, shape = 1.3	scale = 0.013, shape = 1.3	scale = 0.024, shape = 1.3	scale = 0.024, shape = 1.3
–+-	summary	mean = 39, median = 31.9	mean = 34.3, median = 28	mean = 70.5, median = 57.5	mean = 39, median = 31.9	mean = 39, median = 31.9
–+-	effect	af = 1, hr = 1	af = 0.88, hr = 1.18	af = 1.8, hr = 0.46	af = 1, hr = 1	af = 1, hr = 1
–++	param	scale = 0.024, shape = 1.3	scale = 0.027, shape = 1.3	scale = 0.013, shape = 1.3	scale = 0.024, shape = 1.3	scale = 0.024, shape = 1.3
–++	summary	mean = 39, median = 31.9	mean = 34.3, median = 28	mean = 70.5, median = 57.5	mean = 39, median = 31.9	mean = 39, median = 31.9
–++	effect	af = 1, hr = 1	af = 0.88, hr = 1.18	af = 1.8, hr = 0.46	af = 1, hr = 1	af = 1, hr = 1
-+–	param	scale = 0.024, shape = 1.3	scale = 0.027, shape = 1.3	scale = 0.024, shape = 1.3	scale = 0.024, shape = 1.3	scale = 0.024, shape = 1.3
-+–	summary	mean = 39, median = 31.9	mean = 34.3, median = 28	mean = 39, median = 31.9	mean = 39, median = 31.9	mean = 39, median = 31.9
-+–	effect	af = 1, hr = 1	af = 0.88, hr = 1.18	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
-+-+	param	scale = 0.024, shape = 1.3	scale = 0.027, shape = 1.3	scale = 0.024, shape = 1.3	scale = 0.024, shape = 1.3	scale = 0.024, shape = 1.3
-+-+	summary	mean = 39, median = 31.9	mean = 34.3, median = 28	mean = 39, median = 31.9	mean = 39, median = 31.9	mean = 39, median = 31.9
-+-+	effect	af = 1, hr = 1	af = 0.88, hr = 1.18	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
-++-	param	scale = 0.024, shape = 1.3	scale = 0.027, shape = 1.3	scale = 0.013, shape = 1.3	scale = 0.024, shape = 1.3	scale = 0.024, shape = 1.3
-++-	summary	mean = 39, median = 31.9	mean = 34.3, median = 28	mean = 70.5, median = 57.5	mean = 39, median = 31.9	mean = 39, median = 31.9
-++-	effect	af = 1, hr = 1	af = 0.88, hr = 1.18	af = 1.8, hr = 0.46	af = 1, hr = 1	af = 1, hr = 1
-+++	param	scale = 0.024, shape = 1.3	scale = 0.027, shape = 1.3	scale = 0.013, shape = 1.3	scale = 0.024, shape = 1.3	scale = 0.024, shape = 1.3
-+++	summary	mean = 39, median = 31.9	mean = 34.3, median = 28	mean = 70.5, median = 57.5	mean = 39, median = 31.9	mean = 39, median = 31.9
-+++	effect	af = 1, hr = 1	af = 0.88, hr = 1.18	af = 1.8, hr = 0.46	af = 1, hr = 1	af = 1, hr = 1
+—	param	scale = 0.024, shape = 1.3	scale = 0.027, shape = 1.3	scale = 0.024, shape = 1.3	scale = 0.024, shape = 1.3	scale = 0.024, shape = 1.3
+—	summary	mean = 39, median = 31.9	mean = 34.3, median = 28	mean = 39, median = 31.9	mean = 39, median = 31.9	mean = 39, median = 31.9
+—	effect	af = 1, hr = 1	af = 0.88, hr = 1.18	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
+–+	param	scale = 0.024, shape = 1.3	scale = 0.027, shape = 1.3	scale = 0.024, shape = 1.3	scale = 0.024, shape = 1.3	scale = 0.024, shape = 1.3
+–+	summary	mean = 39, median = 31.9	mean = 34.3, median = 28	mean = 39, median = 31.9	mean = 39, median = 31.9	mean = 39, median = 31.9
+–+	effect	af = 1, hr = 1	af = 0.88, hr = 1.18	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
+-+-	param	scale = 0.024, shape = 1.3	scale = 0.027, shape = 1.3	scale = 0.013, shape = 1.3	scale = 0.024, shape = 1.3	scale = 0.024, shape = 1.3
+-+-	summary	mean = 39, median = 31.9	mean = 34.3, median = 28	mean = 70.5, median = 57.5	mean = 39, median = 31.9	mean = 39, median = 31.9
+-+-	effect	af = 1, hr = 1	af = 0.88, hr = 1.18	af = 1.8, hr = 0.46	af = 1, hr = 1	af = 1, hr = 1
+-++	param	scale = 0.024, shape = 1.3	scale = 0.027, shape = 1.3	scale = 0.013, shape = 1.3	scale = 0.024, shape = 1.3	scale = 0.024, shape = 1.3
+-++	summary	mean = 39, median = 31.9	mean = 34.3, median = 28	mean = 70.5, median = 57.5	mean = 39, median = 31.9	mean = 39, median = 31.9
+-++	effect	af = 1, hr = 1	af = 0.88, hr = 1.18	af = 1.8, hr = 0.46	af = 1, hr = 1	af = 1, hr = 1
++–	param	scale = 0.024, shape = 1.3	scale = 0.027, shape = 1.3	scale = 0.024, shape = 1.3	scale = 0.024, shape = 1.3	scale = 0.024, shape = 1.3
++–	summary	mean = 39, median = 31.9	mean = 34.3, median = 28	mean = 39, median = 31.9	mean = 39, median = 31.9	mean = 39, median = 31.9
++–	effect	af = 1, hr = 1	af = 0.88, hr = 1.18	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
++-+	param	scale = 0.024, shape = 1.3	scale = 0.027, shape = 1.3	scale = 0.024, shape = 1.3	scale = 0.024, shape = 1.3	scale = 0.024, shape = 1.3
++-+	summary	mean = 39, median = 31.9	mean = 34.3, median = 28	mean = 39, median = 31.9	mean = 39, median = 31.9	mean = 39, median = 31.9
++-+	effect	af = 1, hr = 1	af = 0.88, hr = 1.18	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
+++-	param	scale = 0.024, shape = 1.3	scale = 0.027, shape = 1.3	scale = 0.013, shape = 1.3	scale = 0.024, shape = 1.3	scale = 0.024, shape = 1.3
+++-	summary	mean = 39, median = 31.9	mean = 34.3, median = 28	mean = 70.5, median = 57.5	mean = 39, median = 31.9	mean = 39, median = 31.9
+++-	effect	af = 1, hr = 1	af = 0.88, hr = 1.18	af = 1.8, hr = 0.46	af = 1, hr = 1	af = 1, hr = 1
++++	param	scale = 0.024, shape = 1.3	scale = 0.027, shape = 1.3	scale = 0.013, shape = 1.3	scale = 0.024, shape = 1.3	scale = 0.024, shape = 1.3
++++	summary	mean = 39, median = 31.9	mean = 34.3, median = 28	mean = 70.5, median = 57.5	mean = 39, median = 31.9	mean = 39, median = 31.9
++++	effect	af = 1, hr = 1	af = 0.88, hr = 1.18	af = 1.8, hr = 0.46	af = 1, hr = 1	af = 1, hr = 1

Errors and power

graduation (counts and proportions):

TC1 TC2 TC3 TC4 all 4 72 10 5 HRD+ 2 38 11 13 TP53+ 4 68 9 9 TEfus+ 0 279 1 3 PI3K+ 1 77 7 4

TC1 TC2 TC3 TC4 all 0.008 0.144 0.020 0.010 HRD+ 0.004 0.076 0.022 0.026 TP53+ 0.008 0.136 0.018 0.018 TEfus+ 0.000 0.558 0.002 0.006 PI3K+ 0.002 0.154 0.014 0.008

futility (counts and proportions):

TC1 TC2 TC3 TC4 all 49 0 3 3 HRD+ 10 1 16 11 TP53+ 185 10 86 77 TEfus+ 219 0 142 121 PI3K+ 160 0 70 91

TC1 TC2 TC3 TC4 all 0.098 0.000 0.006 0.006 HRD+ 0.020 0.002 0.032 0.022 TP53+ 0.370 0.020 0.172 0.154 TEfus+ 0.438 0.000 0.284 0.242 PI3K+ 0.320 0.000 0.140 0.182

max sample size (counts and proportions):

TC1 TC2 TC3 TC4 all 0 0 0 0 HRD+ 0 0 0 0 TP53+ 0 0 0 0 TEfus+ 0 0 0 0 PI3K+ 0 0 0 0

TC1 TC2 TC3 TC4 all 0 0 0 0 HRD+ 0 0 0 0 TP53+ 0 0 0 0 TEfus+ 0 0 0 0 PI3K+ 0 0 0 0

Operating characteristics

Characteristics	Overall	TC1	TC2	TC3	TC4
Error signature	0.306	0.022	0.178	0.07	0.064
Error subgroup	0.484	0.022	0.382	0.07	0.064
Power signature	0.558	0.000	0.558	0.00	0.000
Power subgroup	0.736	0.000	0.736	0.00	0.000

Median results at the end of the trial

By signature:

signature	var	Control	TC1	TC2	TC3	TC4
all	graduation	0	4	72	10	5
all	futility	0	49	0	3	3
all	max_n	0	0	0	0	0
all	n	615 (569, 666)	227 (160, 329)	319 (192, 429)	306 (214, 416)	316 (227, 420)
all	n_unique	615 (569, 666)	227 (160, 329)	319 (192, 429)	306 (214, 416)	316 (227, 420)
all	time_trial	60 (60, 60)	60 (60, 60)	60 (42, 60)	60 (60, 60)	60 (60, 60)
all	time_stop	NA (NA, NA)	42 (16, 58)	30 (11, 55)	19 (12, 56)	18 (11, 36)
all	post_p	NA (NA, NA)	0.04 (0, 0.3)	0.99 (0.83, 1)	0.44 (0.08, 0.86)	0.45 (0.08, 0.9)
all	rate	0.02 (0.019, 0.022)	0.025 (0.023, 0.029)	0.017 (0.015, 0.019)	0.021 (0.019, 0.024)	0.021 (0.019, 0.024)
HRD+	graduation	0	2	38	11	13
HRD+	futility	0	10	1	16	11
HRD+	max_n	0	0	0	0	0
HRD+	n	83 (70, 99)	37 (23, 55)	43 (22, 60)	49 (33, 68)	45 (29, 65)
HRD+	n_unique	83 (70, 99)	37 (23, 55)	43 (22, 60)	49 (33, 68)	45 (29, 65)
HRD+	time_trial	60 (60, 60)	60 (60, 60)	60 (60, 60)	60 (60, 60)	60 (60, 60)
HRD+	time_stop	NA (NA, NA)	57 (52, 60)	52 (43, 58)	52 (42, 58)	56 (42, 59)
HRD+	post_p	NA (NA, NA)	0.24 (0.03, 0.7)	0.81 (0.39, 0.97)	0.46 (0.1, 0.84)	0.44 (0.08, 0.83)
HRD+	rate	0.02 (0.016, 0.025)	0.025 (0.019, 0.035)	0.016 (0.012, 0.022)	0.021 (0.017, 0.028)	0.021 (0.016, 0.029)
TP53+	graduation	0	4	68	9	9
TP53+	futility	0	185	10	86	77
TP53+	max_n	0	0	0	0	0
TP53+	n	228 (200, 254)	84 (51, 133)	118 (65, 172)	112 (61, 163)	118 (62, 166)
TP53+	n_unique	228 (200, 254)	84 (51, 133)	118 (65, 172)	112 (61, 163)	118 (62, 166)
TP53+	time_trial	60 (60, 60)	60 (34, 60)	60 (44, 60)	60 (41, 60)	60 (39, 60)
TP53+	time_stop	NA (NA, NA)	41 (28, 56)	39 (24, 54)	41 (29, 56)	35 (25, 54)
TP53+	post_p	NA (NA, NA)	0.14 (0.01, 0.55)	0.94 (0.61, 1)	0.44 (0.08, 0.86)	0.45 (0.1, 0.85)
TP53+	rate	0.02 (0.018, 0.023)	0.025 (0.021, 0.031)	0.016 (0.014, 0.02)	0.021 (0.018, 0.025)	0.021 (0.018, 0.026)
TEfus+	graduation	0	0	279	1	3
TEfus+	futility	0	219	0	142	121
TEfus+	max_n	0	0	0	0	0
TEfus+	n	202 (177, 225)	70 (50, 113)	111 (54, 172)	90 (54, 142)	90 (56, 146)
TEfus+	n_unique	202 (177, 225)	70 (50, 113)	111 (54, 172)	90 (54, 142)	90 (56, 146)
TEfus+	time_trial	60 (60, 60)	60 (37, 60)	54 (30, 60)	60 (40, 60)	60 (42, 60)
TEfus+	time_stop	NA (NA, NA)	45 (33, 56)	38 (26, 55)	44 (32, 57)	44 (31, 56)
TEfus+	post_p	NA (NA, NA)	0.04 (0, 0.3)	1 (0.95, 1)	0.17 (0.01, 0.61)	0.18 (0.01, 0.63)
TEfus+	rate	0.018 (0.015, 0.02)	0.025 (0.021, 0.031)	0.01 (0.008, 0.013)	0.022 (0.018, 0.026)	0.021 (0.018, 0.026)
PI3K+	graduation	0	1	77	7	4
PI3K+	futility	0	160	0	70	91
PI3K+	max_n	0	0	0	0	0
PI3K+	n	215 (191, 238)	80 (50, 122)	112 (60, 166)	104 (58, 154)	110 (59, 159)
PI3K+	n_unique	215 (191, 238)	80 (50, 122)	112 (60, 166)	104 (58, 154)	110 (59, 159)
PI3K+	time_trial	60 (60, 60)	60 (36, 60)	60 (46, 60)	60 (46, 60)	60 (36, 60)
PI3K+	time_stop	NA (NA, NA)	43 (30, 55)	41 (28, 56)	40 (30, 54)	34 (24, 54)
PI3K+	post_p	NA (NA, NA)	0.1 (0.01, 0.45)	0.96 (0.74, 1)	0.35 (0.07, 0.8)	0.33 (0.07, 0.81)
PI3K+	rate	0.02 (0.017, 0.022)	0.025 (0.021, 0.032)	0.015 (0.012, 0.018)	0.021 (0.018, 0.026)	0.021 (0.018, 0.026)

By subgroup combinations:

subtype	var	Control	TC1	TC2	TC3	TC4
—-	graduation	0	4	72	10	5
—-	futility	0	49	0	3	3
—-	max_n	0	0	0	0	0
—-	n	189 (159, 222)	54 (26, 123)	78 (28, 166)	90 (31, 167)	100 (33, 175)
—-	n_unique	189 (159, 222)	54 (26, 123)	78 (28, 166)	90 (31, 167)	100 (33, 175)
—-	post_p	NA (NA, NA)	0.24 (0.03, 0.68)	0.54 (0.14, 0.93)	0.54 (0.14, 0.92)	0.58 (0.14, 0.94)
—-	rate	0.022 (0.019, 0.025)	0.026 (0.022, 0.035)	0.022 (0.018, 0.029)	0.022 (0.017, 0.029)	0.021 (0.017, 0.029)
—+	graduation	0	5	131	17	9
—+	futility	0	180	0	70	92
—+	max_n	0	0	0	0	0
—+	n	43 (33, 55)	16 (8, 33)	18 (7, 37)	21 (9, 43)	22 (9, 43)
—+	n_unique	43 (33, 55)	16 (8, 33)	18 (7, 37)	21 (9, 43)	22 (9, 43)
—+	post_p	NA (NA, NA)	0.34 (0.1, 0.74)	0.55 (0.18, 0.88)	0.56 (0.17, 0.9)	0.52 (0.15, 0.9)
—+	rate	0.022 (0.016, 0.029)	0.027 (0.018, 0.04)	0.021 (0.014, 0.034)	0.021 (0.014, 0.035)	0.023 (0.015, 0.036)
–+-	graduation	0	4	322	11	8
–+-	futility	0	236	0	142	122
–+-	max_n	0	0	0	0	0
–+-	n	12 (8, 18)	6 (3, 11)	7 (3, 13)	6 (3, 13)	7 (3, 12)
–+-	n_unique	12 (8, 18)	6 (3, 11)	7 (3, 13)	6 (3, 13)	7 (3, 12)
–+-	post_p	NA (NA, NA)	0.36 (0.14, 0.62)	0.66 (0.39, 0.88)	0.45 (0.19, 0.73)	0.45 (0.19, 0.71)
–+-	rate	0.017 (0.008, 0.028)	0.026 (0.012, 0.055)	0.01 (0.002, 0.025)	0.022 (0.008, 0.047)	0.021 (0.008, 0.05)
–++	graduation	0	5	342	17	12
–++	futility	0	300	0	174	176
–++	max_n	0	0	0	0	0
–++	n	68 (55, 81)	18 (8, 42)	37 (16, 66)	22 (10, 54)	24 (12, 57)
–++	n_unique	68 (55, 81)	18 (8, 42)	37 (16, 66)	22 (10, 54)	24 (12, 57)
–++	post_p	NA (NA, NA)	0.17 (0.03, 0.52)	0.94 (0.72, 1)	0.3 (0.06, 0.73)	0.28 (0.06, 0.7)
–++	rate	0.018 (0.013, 0.022)	0.027 (0.018, 0.042)	0.01 (0.007, 0.015)	0.022 (0.015, 0.034)	0.023 (0.016, 0.032)
-+–	graduation	0	7	123	19	14
-+–	futility	0	197	9	86	78
-+–	max_n	0	0	0	0	0
-+–	n	79 (63, 96)	26 (12, 57)	34 (16, 69)	37 (13, 71)	41 (15, 70)
-+–	n_unique	79 (63, 96)	26 (12, 57)	34 (16, 69)	37 (13, 71)	41 (15, 70)
-+–	post_p	NA (NA, NA)	0.33 (0.07, 0.73)	0.56 (0.15, 0.92)	0.57 (0.15, 0.92)	0.58 (0.16, 0.92)
-+–	rate	0.022 (0.018, 0.027)	0.026 (0.02, 0.037)	0.022 (0.016, 0.031)	0.021 (0.015, 0.033)	0.021 (0.016, 0.033)
-+-+	graduation	0	7	163	24	17
-+-+	futility	0	264	9	127	134
-+-+	max_n	0	0	0	0	0
-+-+	n	52 (41, 65)	17 (8, 40)	22 (10, 46)	25 (9, 50)	26 (11, 51)
-+-+	n_unique	52 (41, 65)	17 (8, 40)	22 (10, 46)	25 (9, 50)	26 (11, 51)
-+-+	post_p	NA (NA, NA)	0.36 (0.07, 0.73)	0.56 (0.18, 0.89)	0.54 (0.15, 0.87)	0.55 (0.17, 0.88)
-+-+	rate	0.022 (0.017, 0.028)	0.026 (0.018, 0.042)	0.022 (0.016, 0.034)	0.022 (0.015, 0.035)	0.022 (0.015, 0.034)
-++-	graduation	0	7	342	19	17
-++-	futility	0	325	6	198	171
-++-	max_n	0	0	0	0	0
-++-	n	49 (38, 61)	14 (7, 32)	26 (11, 50)	18 (8, 39)	18 (8, 39)
-++-	n_unique	49 (38, 61)	14 (7, 32)	26 (11, 50)	18 (8, 39)	18 (8, 39)
-++-	post_p	NA (NA, NA)	0.23 (0.05, 0.61)	0.91 (0.6, 0.99)	0.31 (0.07, 0.76)	0.34 (0.07, 0.76)
-++-	rate	0.018 (0.013, 0.023)	0.026 (0.017, 0.04)	0.011 (0.006, 0.016)	0.022 (0.014, 0.036)	0.022 (0.014, 0.035)
-+++	graduation	0	7	355	23	20
-+++	futility	0	360	6	218	208
-+++	max_n	0	0	0	0	0
-+++	n	37 (28, 47)	12 (6, 28)	18 (7, 35)	15 (7, 33)	16 (7, 36)
-+++	n_unique	37 (28, 47)	12 (6, 28)	18 (7, 35)	15 (7, 33)	16 (7, 36)
-+++	post_p	NA (NA, NA)	0.23 (0.05, 0.6)	0.88 (0.56, 0.99)	0.34 (0.1, 0.72)	0.37 (0.08, 0.72)
-+++	rate	0.017 (0.012, 0.024)	0.026 (0.015, 0.043)	0.01 (0.005, 0.017)	0.022 (0.013, 0.035)	0.022 (0.014, 0.036)
+—	graduation	0	6	108	21	18
+—	futility	0	59	1	19	14
+—	max_n	0	0	0	0	0
+—	n	39 (31, 50)	15 (7, 31)	18 (7, 33)	23 (12, 39)	20 (9, 36)
+—	n_unique	39 (31, 50)	15 (7, 31)	18 (7, 33)	23 (12, 39)	20 (9, 36)
+—	post_p	NA (NA, NA)	0.4 (0.09, 0.81)	0.56 (0.18, 0.89)	0.57 (0.17, 0.88)	0.53 (0.16, 0.88)
+—	rate	0.023 (0.016, 0.029)	0.026 (0.015, 0.044)	0.021 (0.013, 0.034)	0.022 (0.015, 0.032)	0.022 (0.013, 0.036)
+–+	graduation	0	7	161	28	22
+–+	futility	0	184	1	85	102
+–+	max_n	0	0	0	0	0
+–+	n	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
+–+	n_unique	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
+–+	post_p	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
+–+	rate	0.032 (0, 0.139)	0.063 (0.063, 0.063)	0 (0, 0)	0.143 (0.093, 0.193)	0.118 (0.118, 0.118)
+-+-	graduation	0	6	340	21	20
+-+-	futility	0	241	1	153	131
+-+-	max_n	0	0	0	0	0
+-+-	n	29 (21, 37)	11 (5, 23)	13 (4, 26)	14 (7, 26)	13 (6, 26)
+-+-	n_unique	29 (21, 37)	11 (5, 23)	13 (4, 26)	14 (7, 26)	13 (6, 26)
+-+-	post_p	NA (NA, NA)	0.26 (0.07, 0.63)	0.8 (0.43, 0.97)	0.35 (0.09, 0.74)	0.36 (0.1, 0.76)
+-+-	rate	0.017 (0.012, 0.026)	0.026 (0.015, 0.047)	0.01 (0.004, 0.021)	0.023 (0.014, 0.038)	0.022 (0.012, 0.039)
+-++	graduation	0	7	356	27	24
+-++	futility	0	303	1	184	184
+-++	max_n	0	0	0	0	0
+-++	n	6 (3, 10)	3 (1, 6)	3 (0, 6)	4 (1, 7)	4 (1, 8)
+-++	n_unique	6 (3, 10)	3 (1, 6)	3 (0, 6)	4 (1, 7)	4 (1, 8)
+-++	post_p	NA (NA, NA)	0.44 (0.28, 0.63)	0.58 (0.43, 0.75)	0.47 (0.3, 0.64)	0.46 (0.32, 0.65)
+-++	rate	0.017 (0, 0.04)	0.027 (0, 0.07)	0.009 (0, 0.033)	0.023 (0.006, 0.056)	0.023 (0, 0.054)
++–	graduation	0	9	154	29	26
++–	futility	0	201	8	99	88
++–	max_n	0	0	0	0	0
++–	n	1 (0, 3)	0 (0, 2)	0 (0, 2)	1 (0, 2)	1 (0, 2)
++–	n_unique	1 (0, 3)	0 (0, 2)	0 (0, 2)	1 (0, 2)	1 (0, 2)
++–	post_p	NA (NA, NA)	0.5 (0.42, 0.57)	0.5 (0.43, 0.56)	0.5 (0.43, 0.57)	0.5 (0.43, 0.58)
++–	rate	0.022 (0, 0.093)	0.024 (0, 0.089)	0.02 (0, 0.091)	0.019 (0, 0.094)	0.016 (0, 0.087)
++-+	graduation	0	9	190	34	29
++-+	futility	0	265	8	139	143
++-+	max_n	0	0	0	0	0
++-+	n	8 (4, 12)	4 (1, 7)	4 (1, 8)	5 (2, 9)	5 (2, 10)
++-+	n_unique	8 (4, 12)	4 (1, 7)	4 (1, 8)	5 (2, 9)	5 (2, 10)
++-+	post_p	NA (NA, NA)	0.44 (0.25, 0.71)	0.51 (0.3, 0.76)	0.5 (0.25, 0.75)	0.49 (0.25, 0.73)
++-+	rate	0.022 (0.01, 0.044)	0.028 (0.008, 0.067)	0.022 (0, 0.056)	0.023 (0.008, 0.055)	0.024 (0.009, 0.052)
+++-	graduation	0	9	357	28	28
+++-	futility	0	327	5	208	180
+++-	max_n	0	0	0	0	0
+++-	n	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
+++-	n_unique	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
+++-	post_p	NA (NA, NA)	NA (NA, NA)	0.55 (0.55, 0.55)	NA (NA, NA)	0.49 (0.49, 0.49)
+++-	rate	0.033 (0.031, 0.075)	0.026 (0.005, 0.046)	0 (0, 0)	0 (0, 0.045)	0.037 (0.037, 0.037)
++++	graduation	0	9	367	32	31
++++	futility	0	361	5	227	216
++++	max_n	0	0	0	0	0
++++	n	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
++++	n_unique	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
++++	post_p	NA (NA, NA)	0.5 (0.46, 0.53)	0.45 (0.45, 0.45)	0.46 (0.46, 0.46)	0.51 (0.51, 0.51)
++++	rate	0.018 (0, 0.177)	0 (0, 0.06)	0 (0, 0.109)	0.03 (0, 0.154)	0 (0, 0.053)

Median results over time

Signatures:

Posterior probabilities

Randomization probabilities

PFS rates

Subgroup combinations:

Posterior probabilities

Randomization probabilities

PFS rates

Median results at stop

By signature

Graduation:

signature	var	TC1	TC2	TC3	TC4
all	count	4	72	10	5
all	time_stop	12 (10, 21)	30 (11, 55)	14 (12, 24)	14 (12, 22)
all	n_trt	68 (57, 128)	176 (68, 319)	80 (61, 147)	72 (60, 113)
all	n_control	102 (83, 169)	266 (92, 546)	112 (99, 208)	113 (96, 200)
all	post_p	0.92 (0.9, 0.97)	0.98 (0.89, 1)	0.95 (0.9, 0.97)	0.87 (0.86, 0.97)
all	order	1 (1, 1)	1 (1, 3)	1 (1, 1.1)	1 (1, 1)
HRD+	count	2	38	11	13
HRD+	time_stop	50 (43, 56)	52 (43, 58)	49 (42, 57)	54 (42, 60)
HRD+	n_trt	56 (55, 56)	52 (50, 61)	52 (50, 68)	54 (50, 64)
HRD+	n_control	58 (51, 64)	66 (54, 85)	64 (47, 90)	69 (58, 79)
HRD+	post_p	0.9 (0.89, 0.91)	0.94 (0.88, 0.98)	0.96 (0.91, 0.98)	0.93 (0.88, 0.98)
HRD+	order	2 (1.2, 2.8)	1 (1, 2.3)	1 (1, 2)	2 (1, 2)
TP53+	count	4	68	9	9
TP53+	time_stop	25 (23, 27)	42 (28, 55)	29 (24, 47)	35 (26, 47)
TP53+	n_trt	50 (50, 54)	99 (66, 152)	57 (51, 118)	73 (56, 133)
TP53+	n_control	70 (60, 85)	138 (79, 196)	100 (75, 154)	124 (87, 167)
TP53+	post_p	0.92 (0.9, 0.97)	0.98 (0.93, 1)	0.99 (0.97, 1)	0.96 (0.93, 0.99)
TP53+	order	1 (1, 1)	1 (1, 3)	1 (1, 1)	1 (1, 2.2)
TEfus+	count		279	1	3
TEfus+	time_stop		38 (26, 55)	34 (34, 34)	29 (25, 35)
TEfus+	n_trt		90 (57, 147)	52 (52, 52)	59 (57, 61)
TEfus+	n_control		112 (67, 176)	102 (102, 102)	86 (72, 103)
TEfus+	post_p		0.99 (0.94, 1)	0.94 (0.94, 0.94)	0.93 (0.9, 0.98)
TEfus+	order		1 (1, 2)	1 (1, 1)	1 (1, 1)
PI3K+	count	1	77	7	4
PI3K+	time_stop	35 (35, 35)	41 (28, 56)	33 (31, 42)	28 (23, 49)
PI3K+	n_trt	74 (74, 74)	87 (53, 129)	65 (54, 72)	62 (56, 157)
PI3K+	n_control	119 (119, 119)	125 (76, 207)	101 (85, 158)	70 (66, 165)
PI3K+	post_p	0.91 (0.91, 0.91)	0.99 (0.94, 1)	0.95 (0.9, 0.99)	0.93 (0.88, 0.99)
PI3K+	order	1 (1, 1)	2 (1, 3.4)	2 (1, 2)	1.5 (1, 2.7)

Futility:

signature	var	TC1	TC2	TC3	TC4
all	count	49		3	3
all	time_stop	46 (21, 58)		58 (48, 59)	30 (13, 45)
all	n_trt	159 (94, 229)		193 (168, 231)	122 (68, 145)
all	n_control	436 (166, 602)		608 (472, 612)	249 (107, 451)
all	post_p	0 (0, 0.03)		0 (0, 0.02)	0.13 (0.03, 0.22)
all	order	3 (1, 6)		3 (2.2, 3.8)	2 (1.2, 3.6)
HRD+	count	10	1	16	11
HRD+	time_stop	57 (56, 60)	58 (58, 58)	54 (42, 59)	57 (53, 58)
HRD+	n_trt	54 (50, 61)	61 (61, 61)	53 (50, 58)	54 (50, 63)
HRD+	n_control	82 (74, 88)	90 (90, 90)	71 (52, 86)	82 (76, 87)
HRD+	post_p	0.06 (0.03, 0.19)	0.2 (0.2, 0.2)	0.19 (0.01, 0.28)	0.14 (0.06, 0.24)
HRD+	order	3.5 (2, 6)	5 (5, 5)	3 (1, 4.5)	3 (2, 5)
TP53+	count	185	10	86	77
TP53+	time_stop	41 (29, 56)	24 (22, 41)	41 (30, 56)	35 (25, 53)
TP53+	n_trt	69 (51, 108)	61 (52, 84)	69 (51, 112)	62 (51, 87)
TP53+	n_control	140 (90, 210)	80 (65, 141)	146 (99, 213)	121 (76, 199)
TP53+	post_p	0.07 (0.01, 0.2)	0.21 (0.02, 0.28)	0.11 (0.04, 0.21)	0.14 (0.03, 0.23)
TP53+	order	2 (1, 4)	1 (1, 1.4)	2 (1, 4)	1 (1, 3)
TEfus+	count	219		142	121
TEfus+	time_stop	45 (33, 56)		44 (32, 57)	44 (32, 56)
TEfus+	n_trt	61 (51, 92)		63 (51, 101)	66 (51, 98)
TEfus+	n_control	139 (89, 191)		134 (92, 190)	139 (80, 189)
TEfus+	post_p	0.04 (0, 0.16)		0.05 (0.01, 0.18)	0.06 (0, 0.2)
TEfus+	order	2 (1, 4)		2 (1, 4)	2 (1, 4)
PI3K+	count	160		70	91
PI3K+	time_stop	44 (30, 55)		41 (30, 54)	35 (24, 53)
PI3K+	n_trt	65 (50, 103)		62 (50, 99)	63 (51, 95)
PI3K+	n_control	147 (87, 199)		134 (78, 185)	99 (66, 189)
PI3K+	post_p	0.04 (0.01, 0.19)		0.09 (0.01, 0.22)	0.09 (0.02, 0.25)
PI3K+	order	2 (1, 4)		2 (1, 4)	2 (1, 4)

By subgroup combinations

Graduation:

signature	treatment	var	—-	—+	–+-	–++	-+–	-+-+	-++-	-+++	+—	+–+	+-+-	+-++	++–	++-+	+++-	++++
all	TC1	count	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4
all	TC1	time	12 (10, 21)	12 (10, 21)	12 (10, 21)	12 (10, 21)	12 (10, 21)	12 (10, 21)	12 (10, 21)	12 (10, 21)	12 (10, 21)	12 (10, 21)	12 (10, 21)	12 (10, 21)	12 (10, 21)	12 (10, 21)	12 (10, 21)	12 (10, 21)
all	TC1	n	34 (23, 48)	4 (3, 9)	0 (0, 2)	7 (6, 18)	10 (9, 11)	4 (2, 17)	6 (5, 10)	3 (1, 8)	2 (1, 3)	0 (0, 0)	1 (0, 3)	0 (0, 1)	0 (0, 0)	1 (0, 3)	0 (0, 0)	0 (0, 0)
all	TC1	post_p	0.56 (0.55, 0.6)	0.55 (0.53, 0.56)	0.52 (0.52, 0.52)	0.52 (0.51, 0.56)	0.57 (0.52, 0.65)	0.56 (0.52, 0.78)	0.55 (0.53, 0.58)	0.51 (0.51, 0.52)	0.52 (0.51, 0.55)	NA (NA, NA)	0.53 (0.53, 0.54)	NA (NA, NA)	NA (NA, NA)	0.51 (0.51, 0.52)	NA (NA, NA)	NA (NA, NA)
all	TC1	r_prob	0.37 (0.37, 0.37)	0.27 (0.27, 0.27)	0.18 (0.18, 0.18)	0.07 (0.07, 0.07)	0.18 (0.18, 0.18)	0.07 (0.07, 0.07)	0.12 (0.12, 0.12)	0.06 (0.06, 0.06)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
all	TC1	rate	0.011 (0.009, 0.014)	0 (0, 0.006)	0 (0, 0)	0.005 (0, 0.017)	0 (0, 0.013)	0 (0, 0)	0.004 (0, 0.016)	0 (0, 0.011)	0 (0, 0)	NA (NA, NA)	0 (0, 0)	0 (0, 0)	NA (NA, NA)	0 (0, 0)	NA (NA, NA)	NA (NA, NA)
all	TC2	count	72	72	72	72	72	72	72	72	72	72	72	72	72	72	72	72
all	TC2	time	30 (11, 55)	30 (11, 55)	30 (11, 55)	30 (11, 55)	30 (11, 55)	30 (11, 55)	30 (11, 55)	30 (11, 55)	30 (11, 55)	30 (11, 55)	30 (11, 55)	30 (11, 55)	30 (11, 55)	30 (11, 55)	30 (11, 55)	30 (11, 55)
all	TC2	n	42 (22, 102)	12 (1, 30)	4 (1, 9)	18 (6, 41)	24 (11, 39)	12 (6, 36)	14 (7, 30)	9 (4, 21)	10 (1, 23)	0 (0, 0)	6 (1, 14)	1 (0, 4)	0 (0, 1)	2 (0, 5)	0 (0, 0)	0 (0, 0)
all	TC2	post_p	0.67 (0.55, 0.9)	0.61 (0.51, 0.79)	0.55 (0.51, 0.78)	0.69 (0.52, 0.96)	0.61 (0.52, 0.89)	0.58 (0.51, 0.85)	0.62 (0.52, 0.91)	0.57 (0.52, 0.91)	0.58 (0.51, 0.82)	NA (NA, NA)	0.58 (0.52, 0.89)	0.54 (0.51, 0.61)	0.53 (0.51, 0.56)	0.54 (0.5, 0.63)	NA (NA, NA)	0.5 (0.5, 0.5)
all	TC2	r_prob	0.25 (0.25, 0.25)	0.07 (0.07, 0.07)	0.41 (0.41, 0.41)	0.27 (0.27, 0.27)	0.41 (0.41, 0.41)	0.27 (0.27, 0.27)	0.41 (0.41, 0.41)	0.25 (0.25, 0.25)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
all	TC2	rate	0.015 (0, 0.022)	0.013 (0, 0.023)	0 (0, 0.015)	0.007 (0, 0.014)	0.015 (0, 0.022)	0.013 (0, 0.02)	0.008 (0, 0.014)	0.006 (0, 0.014)	0.009 (0, 0.021)	NA (NA, NA)	0 (0, 0.015)	0 (0, 0.023)	0 (0, 0.032)	0 (0, 0.029)	NA (NA, NA)	0.307 (0.061, 0.553)
all	TC3	count	10	10	10	10	10	10	10	10	10	10	10	10	10	10	10	10
all	TC3	time	14 (12, 24)	14 (12, 24)	14 (12, 24)	14 (12, 24)	14 (12, 24)	14 (12, 24)	14 (12, 24)	14 (12, 24)	14 (12, 24)	14 (12, 24)	14 (12, 24)	14 (12, 24)	14 (12, 24)	14 (12, 24)	14 (12, 24)	14 (12, 24)
all	TC3	n	25 (17, 40)	7 (4, 15)	2 (0, 3)	8 (4, 16)	10 (5, 20)	4 (3, 14)	7 (2, 11)	6 (1, 10)	10 (6, 10)	0 (0, 0)	10 (5, 14)	1 (0, 3)	0 (0, 1)	1 (0, 2)	0 (0, 0)	0 (0, 0)
all	TC3	post_p	0.67 (0.54, 0.81)	0.54 (0.51, 0.6)	0.51 (0.51, 0.53)	0.53 (0.51, 0.61)	0.57 (0.53, 0.72)	0.54 (0.51, 0.59)	0.55 (0.52, 0.69)	0.55 (0.51, 0.6)	0.54 (0.52, 0.6)	NA (NA, NA)	0.53 (0.52, 0.62)	0.55 (0.53, 0.58)	0.51 (0.5, 0.52)	0.51 (0.5, 0.53)	NA (NA, NA)	NA (NA, NA)
all	TC3	r_prob	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.06 (0.06, 0.06)	0.06 (0.06, 0.06)	0.5 (0.5, 0.5)	0.33 (0.33, 0.33)	0.5 (0.5, 0.5)	0.33 (0.33, 0.33)	0.5 (0.5, 0.5)	0.33 (0.33, 0.33)	0.5 (0.5, 0.5)	0.33 (0.33, 0.33)
all	TC3	rate	0.008 (0, 0.014)	0 (0, 0.022)	0 (0, 0.006)	0 (0, 0.017)	0 (0, 0.022)	0 (0, 0.015)	0 (0, 0.001)	0 (0, 0.013)	0.005 (0, 0.021)	NA (NA, NA)	0 (0, 0.015)	0 (0, 0)	0 (0, 0)	0 (0, 0.008)	NA (NA, NA)	NA (NA, NA)
all	TC4	count	5	5	5	5	5	5	5	5	5	5	5	5	5	5	5	5
all	TC4	time	14 (12, 22)	14 (12, 22)	14 (12, 22)	14 (12, 22)	14 (12, 22)	14 (12, 22)	14 (12, 22)	14 (12, 22)	14 (12, 22)	14 (12, 22)	14 (12, 22)	14 (12, 22)	14 (12, 22)	14 (12, 22)	14 (12, 22)	14 (12, 22)
all	TC4	n	28 (13, 36)	8 (2, 10)	1 (0, 3)	13 (8, 16)	8 (3, 13)	9 (5, 11)	6 (5, 8)	5 (3, 9)	2 (2, 7)	0 (0, 0)	4 (1, 7)	1 (0, 2)	0 (0, 1)	1 (0, 2)	0 (0, 0)	0 (0, 0)
all	TC4	post_p	0.59 (0.55, 0.78)	0.53 (0.52, 0.56)	0.54 (0.52, 0.57)	0.59 (0.55, 0.64)	0.56 (0.52, 0.58)	0.56 (0.51, 0.58)	0.53 (0.5, 0.6)	0.56 (0.53, 0.57)	0.54 (0.52, 0.56)	NA (NA, NA)	0.51 (0.51, 0.53)	0.52 (0.51, 0.52)	NA (NA, NA)	0.52 (0.51, 0.53)	NA (NA, NA)	NA (NA, NA)
all	TC4	r_prob	0 (0, 0)	0.33 (0.33, 0.33)	0 (0, 0)	0.33 (0.33, 0.33)	0 (0, 0)	0.33 (0.33, 0.33)	0 (0, 0)	0.31 (0.31, 0.31)	0 (0, 0)	0.33 (0.33, 0.33)	0 (0, 0)	0.33 (0.33, 0.33)	0 (0, 0)	0.33 (0.33, 0.33)	0 (0, 0)	0.33 (0.33, 0.33)
all	TC4	rate	0.006 (0, 0.012)	0 (0, 0.008)	0 (0, 0)	0 (0, 0.008)	0 (0, 0.01)	0.014 (0, 0.021)	0 (0, 0)	0 (0, 0.011)	0 (0, 0.011)	NA (NA, NA)	0 (0, 0.01)	0 (0, 0)	0 (0, 0)	0 (0, 0)	NA (NA, NA)	NA (NA, NA)
HRD+	TC1	count									2	2	2	2	2	2	2	2
HRD+	TC1	time									50 (43, 56)	50 (43, 56)	50 (43, 56)	50 (43, 56)	50 (43, 56)	50 (43, 56)	50 (43, 56)	50 (43, 56)
HRD+	TC1	n									20 (19, 20)	0 (0, 0)	22 (21, 24)	6 (4, 9)	2 (1, 2)	6 (4, 7)	0 (0, 0)	0 (0, 0)
HRD+	TC1	post_p									0.86 (0.86, 0.86)	NA (NA, NA)	0.79 (0.76, 0.82)	0.54 (0.52, 0.56)	0.53 (0.53, 0.53)	0.58 (0.52, 0.63)	NA (NA, NA)	NA (NA, NA)
HRD+	TC1	r_prob									0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
HRD+	TC1	rate									0.013 (0.012, 0.015)	NA (NA, NA)	0.015 (0.012, 0.018)	0.009 (0.002, 0.016)	0.018 (0.004, 0.032)	0.018 (0.015, 0.022)	NA (NA, NA)	NA (NA, NA)
HRD+	TC2	count									38	38	38	38	38	38	38	38
HRD+	TC2	time									52 (43, 58)	52 (43, 58)	52 (43, 58)	52 (43, 58)	52 (43, 58)	52 (43, 58)	52 (43, 58)	52 (43, 58)
HRD+	TC2	n									27 (20, 36)	0 (0, 0)	18 (11, 24)	3 (1, 6)	0 (0, 1)	4 (1, 8)	0 (0, 0)	0 (0, 0)
HRD+	TC2	post_p									0.82 (0.72, 0.92)	NA (NA, NA)	0.81 (0.71, 0.95)	0.56 (0.51, 0.68)	0.53 (0.5, 0.56)	0.57 (0.51, 0.7)	NA (NA, NA)	NA (NA, NA)
HRD+	TC2	r_prob									0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
HRD+	TC2	rate									0.015 (0.009, 0.018)	NA (NA, NA)	0.008 (0.003, 0.013)	0 (0, 0.019)	0 (0, 0.041)	0.014 (0, 0.026)	NA (NA, NA)	0 (0, 0)
HRD+	TC3	count									11	11	11	11	11	11	11	11
HRD+	TC3	time									49 (42, 57)	49 (42, 57)	49 (42, 57)	49 (42, 57)	49 (42, 57)	49 (42, 57)	49 (42, 57)	49 (42, 57)
HRD+	TC3	n									25 (17, 36)	0 (0, 0)	18 (14, 27)	3 (2, 9)	1 (0, 1)	5 (2, 8)	0 (0, 0)	0 (0, 0)
HRD+	TC3	post_p									0.85 (0.75, 0.96)	NA (NA, NA)	0.75 (0.71, 0.82)	0.58 (0.52, 0.68)	0.59 (0.58, 0.6)	0.57 (0.52, 0.76)	NA (NA, NA)	NA (NA, NA)
HRD+	TC3	r_prob									0.5 (0.5, 0.5)	0.33 (0.33, 0.33)	0.5 (0.5, 0.5)	0.33 (0.33, 0.33)	0.5 (0.5, 0.5)	0.33 (0.33, 0.33)	0.5 (0.5, 0.5)	0.33 (0.33, 0.33)
HRD+	TC3	rate									0.014 (0.009, 0.018)	NA (NA, NA)	0.013 (0.01, 0.015)	0.013 (0, 0.02)	0.02 (0, 0.066)	0.011 (0.008, 0.023)	NA (NA, NA)	NA (NA, NA)
HRD+	TC4	count									13	13	13	13	13	13	13	13
HRD+	TC4	time									54 (42, 60)	54 (42, 60)	54 (42, 60)	54 (42, 60)	54 (42, 60)	54 (42, 60)	54 (42, 60)	54 (42, 60)
HRD+	TC4	n									25 (19, 36)	0 (0, 0)	18 (10, 27)	5 (3, 8)	0 (0, 1)	6 (3, 8)	0 (0, 0)	0 (0, 0)
HRD+	TC4	post_p									0.77 (0.73, 0.9)	NA (NA, NA)	0.8 (0.71, 0.92)	0.59 (0.54, 0.67)	0.55 (0.53, 0.56)	0.58 (0.52, 0.86)	NA (NA, NA)	NA (NA, NA)
HRD+	TC4	r_prob									0 (0, 0)	0.33 (0.33, 0.33)	0 (0, 0)	0.33 (0.33, 0.33)	0 (0, 0)	0.33 (0.33, 0.33)	0 (0, 0)	0.33 (0.33, 0.33)
HRD+	TC4	rate									0.015 (0.009, 0.023)	NA (NA, NA)	0.01 (0.006, 0.015)	0.013 (0, 0.024)	0 (0, 0.02)	0.009 (0, 0.035)	NA (NA, NA)	NA (NA, NA)
TP53+	TC1	count					4	4	4	4					4	4	4	4
TP53+	TC1	time					25 (23, 27)	25 (23, 27)	25 (23, 27)	25 (23, 27)					25 (23, 27)	25 (23, 27)	25 (23, 27)	25 (23, 27)
TP53+	TC1	n					23 (22, 25)	10 (7, 11)	10 (8, 14)	7 (5, 10)					1 (0, 2)	0 (0, 1)	0 (0, 0)	0 (0, 0)
TP53+	TC1	post_p					0.84 (0.75, 0.93)	0.69 (0.63, 0.74)	0.61 (0.54, 0.69)	0.55 (0.53, 0.58)					0.51 (0.51, 0.51)	0.51 (0.51, 0.51)	NA (NA, NA)	NA (NA, NA)
TP53+	TC1	r_prob					0.18 (0.18, 0.18)	0.07 (0.07, 0.07)	0.12 (0.12, 0.12)	0.06 (0.06, 0.06)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
TP53+	TC1	rate					0.005 (0.001, 0.007)	0.003 (0, 0.012)	0.004 (0, 0.009)	0.004 (0, 0.013)					0 (0, 0.149)	0 (0, 0)	NA (NA, NA)	NA (NA, NA)
TP53+	TC2	count					68	68	68	68					68	68	68	68
TP53+	TC2	time					42 (28, 55)	42 (28, 55)	42 (28, 55)	42 (28, 55)					42 (28, 55)	42 (28, 55)	42 (28, 55)	42 (28, 55)
TP53+	TC2	n					36 (23, 56)	20 (10, 35)	22 (11, 36)	14 (7, 26)					0 (0, 1)	3 (1, 6)	0 (0, 0)	0 (0, 0)
TP53+	TC2	post_p					0.82 (0.72, 0.95)	0.75 (0.66, 0.9)	0.81 (0.7, 0.97)	0.78 (0.56, 0.96)					0.52 (0.51, 0.53)	0.55 (0.51, 0.64)	NA (NA, NA)	NA (NA, NA)
TP53+	TC2	r_prob					0.41 (0.41, 0.41)	0.27 (0.27, 0.27)	0.41 (0.41, 0.41)	0.25 (0.25, 0.25)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
TP53+	TC2	rate					0.015 (0.01, 0.019)	0.013 (0.008, 0.02)	0.008 (0.004, 0.014)	0.008 (0, 0.012)					0 (0, 0.042)	0.009 (0, 0.024)	NA (NA, NA)	NA (NA, NA)
TP53+	TC3	count					9	9	9	9					9	9	9	9
TP53+	TC3	time					29 (24, 47)	29 (24, 47)	29 (24, 47)	29 (24, 47)					29 (24, 47)	29 (24, 47)	29 (24, 47)	29 (24, 47)
TP53+	TC3	n					23 (17, 31)	17 (9, 32)	10 (7, 18)	8 (6, 18)					0 (0, 1)	4 (0, 6)	0 (0, 0)	0 (0, 0)
TP53+	TC3	post_p					0.81 (0.72, 0.86)	0.77 (0.6, 0.85)	0.68 (0.5, 0.87)	0.57 (0.53, 0.91)					0.54 (0.53, 0.54)	0.59 (0.56, 0.83)	NA (NA, NA)	NA (NA, NA)
TP53+	TC3	r_prob					0 (0, 0)	0 (0, 0)	0.06 (0.06, 0.06)	0.06 (0.06, 0.06)					0.5 (0.5, 0.5)	0.33 (0.33, 0.33)	0.5 (0.5, 0.5)	0.33 (0.33, 0.33)
TP53+	TC3	rate					0.01 (0.004, 0.016)	0.011 (0.004, 0.014)	0.006 (0, 0.014)	0 (0, 0.01)					0 (0, 0.014)	0 (0, 0)	NA (NA, NA)	NA (NA, NA)
TP53+	TC4	count					9	9	9	9					9	9	9	9
TP53+	TC4	time					35 (26, 47)	35 (26, 47)	35 (26, 47)	35 (26, 47)					35 (26, 47)	35 (26, 47)	35 (26, 47)	35 (26, 47)
TP53+	TC4	n					30 (20, 46)	22 (13, 30)	15 (9, 34)	10 (7, 26)					0 (0, 0)	3 (1, 7)	0 (0, 0)	0 (0, 0)
TP53+	TC4	post_p					0.8 (0.73, 0.9)	0.76 (0.7, 0.84)	0.73 (0.52, 0.87)	0.57 (0.51, 0.78)					NA (NA, NA)	0.56 (0.53, 0.76)	NA (NA, NA)	NA (NA, NA)
TP53+	TC4	r_prob					0 (0, 0)	0.33 (0.33, 0.33)	0 (0, 0)	0.31 (0.31, 0.31)					0 (0, 0)	0.33 (0.33, 0.33)	0 (0, 0)	0.33 (0.33, 0.33)
TP53+	TC4	rate					0.011 (0.004, 0.014)	0.011 (0.008, 0.018)	0.01 (0.006, 0.015)	0.01 (0.005, 0.018)					NA (NA, NA)	0 (0, 0.022)	NA (NA, NA)	NA (NA, NA)
TEfus+	TC2	count			279	279			279	279			279	279			279	279
TEfus+	TC2	time			38 (26, 55)	38 (26, 55)			38 (26, 55)	38 (26, 55)			38 (26, 55)	38 (26, 55)			38 (26, 55)	38 (26, 55)
TEfus+	TC2	n			6 (3, 11)	31 (17, 52)			22 (13, 40)	16 (7, 29)			10 (5, 20)	2 (0, 5)			0 (0, 0)	0 (0, 0)
TEfus+	TC2	post_p			0.58 (0.51, 0.76)	0.86 (0.72, 0.99)			0.78 (0.7, 0.97)	0.74 (0.55, 0.94)			0.71 (0.53, 0.91)	0.54 (0.51, 0.66)			0.57 (0.57, 0.57)	NA (NA, NA)
TEfus+	TC2	r_prob			0.41 (0.41, 0.41)	0.27 (0.27, 0.27)			0.41 (0.41, 0.41)	0.25 (0.25, 0.25)			0 (0, 0)	0 (0, 0)			0 (0, 0)	0 (0, 0)
TEfus+	TC2	rate			0.006 (0, 0.018)	0.009 (0.003, 0.013)			0.009 (0.003, 0.014)	0.008 (0, 0.013)			0.007 (0, 0.016)	0 (0, 0.018)			0 (0, 0)	0 (0, 0)
TEfus+	TC3	count			1	1			1	1			1	1			1	1
TEfus+	TC3	time			34 (34, 34)	34 (34, 34)			34 (34, 34)	34 (34, 34)			34 (34, 34)	34 (34, 34)			34 (34, 34)	34 (34, 34)
TEfus+	TC3	n			4 (4, 4)	9 (9, 9)			8 (8, 8)	18 (18, 18)			9 (9, 9)	4 (4, 4)			0 (0, 0)	0 (0, 0)
TEfus+	TC3	post_p			0.6 (0.6, 0.6)	0.83 (0.83, 0.83)			0.55 (0.55, 0.55)	0.77 (0.77, 0.77)			0.52 (0.52, 0.52)	0.52 (0.52, 0.52)			NA (NA, NA)	NA (NA, NA)
TEfus+	TC3	r_prob			0 (0, 0)	0 (0, 0)			0.06 (0.06, 0.06)	0.06 (0.06, 0.06)			0.5 (0.5, 0.5)	0.33 (0.33, 0.33)			0.5 (0.5, 0.5)	0.33 (0.33, 0.33)
TEfus+	TC3	rate			0.016 (0.016, 0.016)	0 (0, 0)			0.008 (0.008, 0.008)	0 (0, 0)			0.018 (0.018, 0.018)	0.012 (0.012, 0.012)			NA (NA, NA)	NA (NA, NA)
TEfus+	TC4	count			3	3			3	3			3	3			3	3
TEfus+	TC4	time			29 (25, 35)	29 (25, 35)			29 (25, 35)	29 (25, 35)			29 (25, 35)	29 (25, 35)			29 (25, 35)	29 (25, 35)
TEfus+	TC4	n			6 (4, 7)	23 (21, 29)			14 (10, 14)	9 (7, 9)			3 (2, 10)	4 (1, 5)			0 (0, 0)	0 (0, 0)
TEfus+	TC4	post_p			0.6 (0.53, 0.63)	0.76 (0.75, 0.78)			0.72 (0.66, 0.74)	0.68 (0.58, 0.88)			0.57 (0.54, 0.84)	0.58 (0.53, 0.63)			NA (NA, NA)	NA (NA, NA)
TEfus+	TC4	r_prob			0 (0, 0)	0.33 (0.33, 0.33)			0 (0, 0)	0.31 (0.31, 0.31)			0 (0, 0)	0.33 (0.33, 0.33)			0 (0, 0)	0.33 (0.33, 0.33)
TEfus+	TC4	rate			0 (0, 0.012)	0.01 (0.006, 0.011)			0.005 (0.001, 0.011)	0 (0, 0.011)			0 (0, 0.004)	0 (0, 0)			NA (NA, NA)	NA (NA, NA)
PI3K+	TC1	count		1		1		1		1		1		1		1		1
PI3K+	TC1	time		35 (35, 35)		35 (35, 35)		35 (35, 35)		35 (35, 35)		35 (35, 35)		35 (35, 35)		35 (35, 35)		35 (35, 35)
PI3K+	TC1	n		12 (12, 12)		27 (27, 27)		16 (16, 16)		18 (18, 18)		0 (0, 0)		0 (0, 0)		1 (1, 1)		0 (0, 0)
PI3K+	TC1	post_p		0.75 (0.75, 0.75)		0.76 (0.76, 0.76)		0.72 (0.72, 0.72)		0.75 (0.75, 0.75)		NA (NA, NA)		NA (NA, NA)		0.52 (0.52, 0.52)		NA (NA, NA)
PI3K+	TC1	r_prob		0.27 (0.27, 0.27)		0.07 (0.07, 0.07)		0.07 (0.07, 0.07)		0.06 (0.06, 0.06)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0 (0, 0)
PI3K+	TC1	rate		0.011 (0.011, 0.011)		0.01 (0.01, 0.01)		0.016 (0.016, 0.016)		0.007 (0.007, 0.007)		NA (NA, NA)		NA (NA, NA)		0 (0, 0)		NA (NA, NA)
PI3K+	TC2	count		77		77		77		77		77		77		77		77
PI3K+	TC2	time		41 (28, 56)		41 (28, 56)		41 (28, 56)		41 (28, 56)		41 (28, 56)		41 (28, 56)		41 (28, 56)		41 (28, 56)
PI3K+	TC2	n		17 (8, 30)		30 (16, 44)		20 (10, 41)		14 (7, 25)		0 (0, 0)		2 (0, 4)		2 (1, 6)		0 (0, 0)
PI3K+	TC2	post_p		0.75 (0.53, 0.9)		0.87 (0.73, 0.99)		0.76 (0.59, 0.9)		0.79 (0.54, 0.92)		NA (NA, NA)		0.54 (0.51, 0.61)		0.55 (0.5, 0.64)		NA (NA, NA)
PI3K+	TC2	r_prob		0.07 (0.07, 0.07)		0.27 (0.27, 0.27)		0.27 (0.27, 0.27)		0.25 (0.25, 0.25)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0 (0, 0)
PI3K+	TC2	rate		0.014 (0.005, 0.024)		0.008 (0.005, 0.013)		0.015 (0.006, 0.022)		0.008 (0, 0.013)		NA (NA, NA)		0 (0, 0.019)		0 (0, 0.027)		NA (NA, NA)
PI3K+	TC3	count		7		7		7		7		7		7		7		7
PI3K+	TC3	time		33 (31, 42)		33 (31, 42)		33 (31, 42)		33 (31, 42)		33 (31, 42)		33 (31, 42)		33 (31, 42)		33 (31, 42)
PI3K+	TC3	n		16 (8, 24)		18 (8, 26)		15 (8, 22)		9 (6, 16)		0 (0, 0)		2 (1, 4)		3 (1, 4)		0 (0, 0)
PI3K+	TC3	post_p		0.73 (0.57, 0.83)		0.75 (0.64, 0.84)		0.78 (0.53, 0.84)		0.76 (0.51, 0.89)		NA (NA, NA)		0.52 (0.51, 0.53)		0.55 (0.51, 0.76)		NA (NA, NA)
PI3K+	TC3	r_prob		0 (0, 0)		0 (0, 0)		0 (0, 0)		0.06 (0.06, 0.06)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)
PI3K+	TC3	rate		0.017 (0.008, 0.019)		0.012 (0.003, 0.017)		0.012 (0.005, 0.019)		0.011 (0, 0.015)		NA (NA, NA)		0 (0, 0.026)		0 (0, 0.01)		NA (NA, NA)
PI3K+	TC4	count		4		4		4		4		4		4		4		4
PI3K+	TC4	time		28 (23, 49)		28 (23, 49)		28 (23, 49)		28 (23, 49)		28 (23, 49)		28 (23, 49)		28 (23, 49)		28 (23, 49)
PI3K+	TC4	n		8 (7, 37)		23 (20, 38)		12 (10, 41)		12 (7, 32)		0 (0, 0)		5 (3, 7)		4 (3, 6)		0 (0, 0)
PI3K+	TC4	post_p		0.71 (0.56, 0.82)		0.74 (0.72, 0.84)		0.62 (0.52, 0.79)		0.65 (0.59, 0.72)		NA (NA, NA)		0.56 (0.52, 0.6)		0.61 (0.57, 0.71)		NA (NA, NA)
PI3K+	TC4	r_prob		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.31 (0.31, 0.31)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)
PI3K+	TC4	rate		0.012 (0.003, 0.015)		0.004 (0.001, 0.008)		0.017 (0.015, 0.023)		0.003 (0, 0.014)		NA (NA, NA)		0.011 (0.003, 0.034)		0 (0, 0.016)		NA (NA, NA)

Futility:

signature	treatment	var	—-	—+	–+-	–++	-+–	-+-+	-++-	-+++	+—	+–+	+-+-	+-++	++–	++-+	+++-	++++
all	TC1	count	49	49	49	49	49	49	49	49	49	49	49	49	49	49	49	49
all	TC1	time	46 (21, 58)	46 (21, 58)	46 (21, 58)	46 (21, 58)	46 (21, 58)	46 (21, 58)	46 (21, 58)	46 (21, 58)	46 (21, 58)	46 (21, 58)	46 (21, 58)	46 (21, 58)	46 (21, 58)	46 (21, 58)	46 (21, 58)	46 (21, 58)
all	TC1	n	41 (23, 83)	12 (7, 19)	5 (1, 9)	13 (8, 24)	20 (11, 38)	11 (5, 26)	11 (5, 20)	9 (3, 20)	10 (5, 20)	0 (0, 0)	7 (3, 13)	2 (0, 4)	0 (0, 1)	3 (0, 5)	0 (0, 0)	0 (0, 0)
all	TC1	post_p	0.22 (0.04, 0.44)	0.3 (0.1, 0.46)	0.4 (0.29, 0.49)	0.2 (0.02, 0.43)	0.29 (0.12, 0.47)	0.35 (0.09, 0.48)	0.28 (0.07, 0.48)	0.36 (0.07, 0.47)	0.37 (0.14, 0.49)	NA (NA, NA)	0.29 (0.07, 0.46)	0.44 (0.31, 0.49)	0.46 (0.37, 0.47)	0.45 (0.33, 0.49)	NA (NA, NA)	NA (NA, NA)
all	TC1	r_prob	0.37 (0.37, 0.37)	0.27 (0.27, 0.27)	0.18 (0.18, 0.18)	0.07 (0.07, 0.07)	0.18 (0.18, 0.18)	0.07 (0.07, 0.07)	0.12 (0.12, 0.12)	0.06 (0.06, 0.06)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
all	TC1	rate	0.027 (0.021, 0.038)	0.032 (0.02, 0.049)	0.026 (0.01, 0.051)	0.029 (0.02, 0.043)	0.028 (0.021, 0.037)	0.029 (0.019, 0.047)	0.025 (0.018, 0.048)	0.024 (0.017, 0.053)	0.028 (0.017, 0.043)	NA (NA, NA)	0.033 (0.019, 0.068)	0.029 (0, 0.086)	0.03 (0, 0.116)	0.031 (0.021, 0.069)	NA (NA, NA)	0 (0, 0)
all	TC3	count	3	3	3	3	3	3	3	3	3	3	3	3	3	3	3	3
all	TC3	time	58 (48, 59)	58 (48, 59)	58 (48, 59)	58 (48, 59)	58 (48, 59)	58 (48, 59)	58 (48, 59)	58 (48, 59)	58 (48, 59)	58 (48, 59)	58 (48, 59)	58 (48, 59)	58 (48, 59)	58 (48, 59)	58 (48, 59)	58 (48, 59)
all	TC3	n	48 (35, 84)	14 (12, 28)	3 (1, 5)	15 (12, 21)	15 (9, 38)	19 (12, 25)	15 (12, 19)	15 (13, 18)	17 (15, 19)	0 (0, 0)	6 (6, 9)	2 (0, 3)	2 (0, 3)	4 (2, 5)	0 (0, 0)	0 (0, 1)
all	TC3	post_p	0.19 (0.17, 0.35)	0.36 (0.32, 0.45)	0.41 (0.36, 0.44)	0.09 (0.06, 0.18)	0.2 (0.13, 0.26)	0.32 (0.21, 0.32)	0.11 (0.05, 0.24)	0.45 (0.19, 0.45)	0.31 (0.17, 0.4)	NA (NA, NA)	0.2 (0.09, 0.41)	0.47 (0.45, 0.48)	0.49 (0.49, 0.49)	0.46 (0.38, 0.48)	NA (NA, NA)	NA (NA, NA)
all	TC3	r_prob	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.06 (0.06, 0.06)	0.06 (0.06, 0.06)	0.5 (0.5, 0.5)	0.33 (0.33, 0.33)	0.5 (0.5, 0.5)	0.33 (0.33, 0.33)	0.5 (0.5, 0.5)	0.33 (0.33, 0.33)	0.5 (0.5, 0.5)	0.33 (0.33, 0.33)
all	TC3	rate	0.024 (0.023, 0.027)	0.023 (0.021, 0.025)	0.027 (0.02, 0.029)	0.034 (0.023, 0.035)	0.034 (0.026, 0.035)	0.027 (0.023, 0.031)	0.024 (0.019, 0.033)	0.014 (0.013, 0.026)	0.022 (0.022, 0.026)	NA (NA, NA)	0.024 (0.021, 0.04)	0.05 (0.031, 0.069)	0.011 (0.01, 0.013)	0.027 (0.022, 0.077)	NA (NA, NA)	0.231 (0.231, 0.231)
all	TC4	count	3	3	3	3	3	3	3	3	3	3	3	3	3	3	3	3
all	TC4	time	30 (13, 45)	30 (13, 45)	30 (13, 45)	30 (13, 45)	30 (13, 45)	30 (13, 45)	30 (13, 45)	30 (13, 45)	30 (13, 45)	30 (13, 45)	30 (13, 45)	30 (13, 45)	30 (13, 45)	30 (13, 45)	30 (13, 45)	30 (13, 45)
all	TC4	n	21 (16, 22)	9 (6, 13)	4 (2, 4)	16 (11, 17)	16 (8, 24)	11 (9, 13)	9 (3, 11)	10 (7, 11)	6 (3, 18)	0 (0, 0)	6 (1, 8)	2 (0, 4)	0 (0, 0)	2 (0, 6)	0 (0, 0)	0 (0, 0)
all	TC4	post_p	0.32 (0.1, 0.4)	0.31 (0.19, 0.44)	0.46 (0.45, 0.47)	0.42 (0.17, 0.43)	0.3 (0.25, 0.44)	0.41 (0.38, 0.43)	0.37 (0.19, 0.47)	0.42 (0.34, 0.43)	0.38 (0.24, 0.46)	NA (NA, NA)	0.21 (0.14, 0.29)	0.49 (0.49, 0.49)	NA (NA, NA)	0.29 (0.21, 0.37)	NA (NA, NA)	NA (NA, NA)
all	TC4	r_prob	0 (0, 0)	0.33 (0.33, 0.33)	0 (0, 0)	0.33 (0.33, 0.33)	0 (0, 0)	0.33 (0.33, 0.33)	0 (0, 0)	0.31 (0.31, 0.31)	0 (0, 0)	0.33 (0.33, 0.33)	0 (0, 0)	0.33 (0.33, 0.33)	0 (0, 0)	0.33 (0.33, 0.33)	0 (0, 0)	0.33 (0.33, 0.33)
all	TC4	rate	0.029 (0.023, 0.03)	0.034 (0.007, 0.037)	0.015 (0.003, 0.022)	0.018 (0.014, 0.022)	0.027 (0.022, 0.087)	0.019 (0.019, 0.028)	0.025 (0.005, 0.034)	0.02 (0.017, 0.027)	0.02 (0.004, 0.071)	NA (NA, NA)	0.038 (0.035, 0.041)	0.027 (0.018, 0.035)	NA (NA, NA)	0.03 (0.029, 0.03)	NA (NA, NA)	NA (NA, NA)
HRD+	TC1	count									10	10	10	10	10	10	10	10
HRD+	TC1	time									57 (56, 60)	57 (56, 60)	57 (56, 60)	57 (56, 60)	57 (56, 60)	57 (56, 60)	57 (56, 60)	57 (56, 60)
HRD+	TC1	n									28 (15, 40)	0 (0, 0)	16 (10, 27)	4 (3, 7)	1 (0, 3)	4 (3, 7)	0 (0, 0)	0 (0, 0)
HRD+	TC1	post_p									0.3 (0.09, 0.47)	NA (NA, NA)	0.23 (0.05, 0.44)	0.43 (0.37, 0.48)	0.45 (0.45, 0.46)	0.28 (0.17, 0.39)	NA (NA, NA)	NA (NA, NA)
HRD+	TC1	r_prob									0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
HRD+	TC1	rate									0.026 (0.02, 0.037)	NA (NA, NA)	0.025 (0.02, 0.045)	0.031 (0.02, 0.042)	0.024 (0, 0.054)	0.038 (0.028, 0.072)	NA (NA, NA)	NA (NA, NA)
HRD+	TC2	count									1	1	1	1	1	1	1	1
HRD+	TC2	time									58 (58, 58)	58 (58, 58)	58 (58, 58)	58 (58, 58)	58 (58, 58)	58 (58, 58)	58 (58, 58)	58 (58, 58)
HRD+	TC2	n									13 (13, 13)	0 (0, 0)	43 (43, 43)	3 (3, 3)	0 (0, 0)	2 (2, 2)	0 (0, 0)	0 (0, 0)
HRD+	TC2	post_p									0.16 (0.16, 0.16)	NA (NA, NA)	0.35 (0.35, 0.35)	0.49 (0.49, 0.49)	NA (NA, NA)	0.47 (0.47, 0.47)	NA (NA, NA)	NA (NA, NA)
HRD+	TC2	r_prob									0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
HRD+	TC2	rate									0.027 (0.027, 0.027)	NA (NA, NA)	0.015 (0.015, 0.015)	0.028 (0.028, 0.028)	NA (NA, NA)	0.015 (0.015, 0.015)	NA (NA, NA)	NA (NA, NA)
HRD+	TC3	count									16	16	16	16	16	16	16	16
HRD+	TC3	time									54 (42, 59)	54 (42, 59)	54 (42, 59)	54 (42, 59)	54 (42, 59)	54 (42, 59)	54 (42, 59)	54 (42, 59)
HRD+	TC3	n									27 (18, 34)	0 (0, 0)	19 (10, 24)	4 (2, 7)	1 (0, 2)	4 (0, 8)	0 (0, 0)	0 (0, 0)
HRD+	TC3	post_p									0.38 (0.19, 0.46)	NA (NA, NA)	0.3 (0.11, 0.46)	0.48 (0.35, 0.49)	0.46 (0.45, 0.48)	0.4 (0.18, 0.48)	NA (NA, NA)	NA (NA, NA)
HRD+	TC3	r_prob									0.5 (0.5, 0.5)	0.33 (0.33, 0.33)	0.5 (0.5, 0.5)	0.33 (0.33, 0.33)	0.5 (0.5, 0.5)	0.33 (0.33, 0.33)	0.5 (0.5, 0.5)	0.33 (0.33, 0.33)
HRD+	TC3	rate									0.024 (0.022, 0.027)	NA (NA, NA)	0.027 (0.015, 0.039)	0.024 (0.018, 0.036)	0.022 (0, 0.074)	0.03 (0.022, 0.051)	NA (NA, NA)	0.095 (0.032, 0.158)
HRD+	TC4	count									11	11	11	11	11	11	11	11
HRD+	TC4	time									57 (53, 58)	57 (53, 58)	57 (53, 58)	57 (53, 58)	57 (53, 58)	57 (53, 58)	57 (53, 58)	57 (53, 58)
HRD+	TC4	n									26 (18, 30)	0 (0, 0)	25 (14, 28)	5 (4, 9)	0 (0, 1)	3 (2, 6)	0 (0, 0)	0 (0, 0)
HRD+	TC4	post_p									0.42 (0.31, 0.48)	NA (NA, NA)	0.33 (0.18, 0.42)	0.43 (0.39, 0.5)	0.49 (0.48, 0.49)	0.41 (0.23, 0.49)	NA (NA, NA)	NA (NA, NA)
HRD+	TC4	r_prob									0 (0, 0)	0.33 (0.33, 0.33)	0 (0, 0)	0.33 (0.33, 0.33)	0 (0, 0)	0.33 (0.33, 0.33)	0 (0, 0)	0.33 (0.33, 0.33)
HRD+	TC4	rate									0.022 (0.016, 0.029)	NA (NA, NA)	0.02 (0.016, 0.028)	0.022 (0.016, 0.029)	0 (0, 0.06)	0.047 (0.019, 0.07)	NA (NA, NA)	NA (NA, NA)
TP53+	TC1	count					185	185	185	185					185	185	185	185
TP53+	TC1	time					41 (29, 56)	41 (29, 56)	41 (29, 56)	41 (29, 56)					41 (29, 56)	41 (29, 56)	41 (29, 56)	41 (29, 56)
TP53+	TC1	n					22 (13, 46)	15 (8, 30)	13 (7, 26)	11 (5, 24)					0 (0, 1)	3 (1, 6)	0 (0, 0)	0 (0, 0)
TP53+	TC1	post_p					0.32 (0.11, 0.48)	0.32 (0.12, 0.47)	0.31 (0.08, 0.47)	0.35 (0.12, 0.48)					0.47 (0.44, 0.49)	0.44 (0.32, 0.5)	NA (NA, NA)	0.44 (0.44, 0.44)
TP53+	TC1	r_prob					0.18 (0.18, 0.18)	0.07 (0.07, 0.07)	0.12 (0.12, 0.12)	0.06 (0.06, 0.06)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
TP53+	TC1	rate					0.026 (0.019, 0.035)	0.027 (0.019, 0.044)	0.025 (0.017, 0.04)	0.024 (0.016, 0.044)					0.024 (0, 0.129)	0.033 (0.016, 0.089)	NA (NA, NA)	0.024 (0, 0.118)
TP53+	TC2	count					10	10	10	10					10	10	10	10
TP53+	TC2	time					24 (22, 41)	24 (22, 41)	24 (22, 41)	24 (22, 41)					24 (22, 41)	24 (22, 41)	24 (22, 41)	24 (22, 41)
TP53+	TC2	n					21 (13, 34)	16 (9, 25)	14 (10, 17)	11 (7, 16)					0 (0, 0)	2 (0, 4)	0 (0, 0)	0 (0, 0)
TP53+	TC2	post_p					0.38 (0.27, 0.47)	0.41 (0.29, 0.49)	0.39 (0.27, 0.45)	0.47 (0.38, 0.49)					NA (NA, NA)	0.47 (0.36, 0.49)	NA (NA, NA)	NA (NA, NA)
TP53+	TC2	r_prob					0.41 (0.41, 0.41)	0.27 (0.27, 0.27)	0.41 (0.41, 0.41)	0.25 (0.25, 0.25)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
TP53+	TC2	rate					0.023 (0.018, 0.032)	0.021 (0.015, 0.029)	0.017 (0.013, 0.03)	0.019 (0.012, 0.021)					NA (NA, NA)	0.012 (0, 0.061)	NA (NA, NA)	NA (NA, NA)
TP53+	TC3	count					86	86	86	86					86	86	86	86
TP53+	TC3	time					41 (30, 56)	41 (30, 56)	41 (30, 56)	41 (30, 56)					41 (30, 56)	41 (30, 56)	41 (30, 56)	41 (30, 56)
TP53+	TC3	n					22 (12, 44)	16 (8, 34)	14 (10, 26)	11 (6, 22)					0 (0, 2)	4 (1, 7)	0 (0, 0)	0 (0, 0)
TP53+	TC3	post_p					0.36 (0.14, 0.48)	0.34 (0.12, 0.48)	0.32 (0.15, 0.46)	0.36 (0.15, 0.48)					0.48 (0.42, 0.49)	0.44 (0.34, 0.49)	NA (NA, NA)	NA (NA, NA)
TP53+	TC3	r_prob					0 (0, 0)	0 (0, 0)	0.06 (0.06, 0.06)	0.06 (0.06, 0.06)					0.5 (0.5, 0.5)	0.33 (0.33, 0.33)	0.5 (0.5, 0.5)	0.33 (0.33, 0.33)
TP53+	TC3	rate					0.024 (0.017, 0.034)	0.026 (0.019, 0.041)	0.022 (0.017, 0.034)	0.022 (0.016, 0.042)					0.019 (0, 0.078)	0.028 (0.012, 0.071)	0 (0, 0)	0.115 (0.023, 0.208)
TP53+	TC4	count					77	77	77	77					77	77	77	77
TP53+	TC4	time					35 (25, 53)	35 (25, 53)	35 (25, 53)	35 (25, 53)					35 (25, 53)	35 (25, 53)	35 (25, 53)	35 (25, 53)
TP53+	TC4	n					19 (11, 35)	15 (8, 27)	12 (5, 23)	11 (7, 16)					0 (0, 1)	3 (1, 6)	0 (0, 0)	0 (0, 0)
TP53+	TC4	post_p					0.35 (0.16, 0.48)	0.35 (0.15, 0.47)	0.37 (0.16, 0.48)	0.38 (0.16, 0.48)					0.47 (0.42, 0.5)	0.45 (0.34, 0.49)	NA (NA, NA)	NA (NA, NA)
TP53+	TC4	r_prob					0 (0, 0)	0.33 (0.33, 0.33)	0 (0, 0)	0.31 (0.31, 0.31)					0 (0, 0)	0.33 (0.33, 0.33)	0 (0, 0)	0.33 (0.33, 0.33)
TP53+	TC4	rate					0.025 (0.018, 0.036)	0.027 (0.019, 0.039)	0.024 (0.016, 0.039)	0.023 (0.014, 0.042)					0.048 (0, 0.156)	0.029 (0, 0.066)	NA (NA, NA)	0 (0, 0)
TEfus+	TC1	count			219	219			219	219			219	219			219	219
TEfus+	TC1	time			45 (33, 56)	45 (33, 56)			45 (33, 56)	45 (33, 56)			45 (33, 56)	45 (33, 56)			45 (33, 56)	45 (33, 56)
TEfus+	TC1	n			5 (3, 10)	17 (9, 33)			13 (7, 26)	12 (6, 24)			9 (5, 16)	3 (1, 6)			0 (0, 0)	0 (0, 0)
TEfus+	TC1	post_p			0.42 (0.22, 0.49)	0.24 (0.06, 0.46)			0.29 (0.07, 0.47)	0.3 (0.09, 0.46)			0.33 (0.11, 0.47)	0.45 (0.35, 0.5)			NA (NA, NA)	0.5 (0.5, 0.5)
TEfus+	TC1	r_prob			0.18 (0.18, 0.18)	0.07 (0.07, 0.07)			0.12 (0.12, 0.12)	0.06 (0.06, 0.06)			0 (0, 0)	0 (0, 0)			0 (0, 0)	0 (0, 0)
TEfus+	TC1	rate			0.028 (0.014, 0.055)	0.025 (0.017, 0.039)			0.026 (0.018, 0.04)	0.024 (0.017, 0.04)			0.027 (0.017, 0.052)	0.033 (0.012, 0.074)			NA (NA, NA)	0 (0, 0.024)
TEfus+	TC3	count			142	142			142	142			142	142			142	142
TEfus+	TC3	time			44 (32, 57)	44 (32, 57)			44 (32, 57)	44 (32, 57)			44 (32, 57)	44 (32, 57)			44 (32, 57)	44 (32, 57)
TEfus+	TC3	n			5 (2, 10)	18 (10, 39)			14 (7, 25)	11 (6, 20)			10 (6, 18)	3 (1, 6)			0 (0, 0)	0 (0, 0)
TEfus+	TC3	post_p			0.43 (0.29, 0.48)	0.31 (0.07, 0.48)			0.31 (0.1, 0.46)	0.37 (0.12, 0.48)			0.31 (0.14, 0.47)	0.44 (0.35, 0.49)			NA (NA, NA)	0.45 (0.45, 0.45)
TEfus+	TC3	r_prob			0 (0, 0)	0 (0, 0)			0.06 (0.06, 0.06)	0.06 (0.06, 0.06)			0.5 (0.5, 0.5)	0.33 (0.33, 0.33)			0.5 (0.5, 0.5)	0.33 (0.33, 0.33)
TEfus+	TC3	rate			0.028 (0.016, 0.06)	0.022 (0.015, 0.038)			0.022 (0.016, 0.041)	0.022 (0.016, 0.04)			0.025 (0.016, 0.039)	0.029 (0.012, 0.057)			NA (NA, NA)	0.043 (0.009, 0.193)
TEfus+	TC4	count			121	121			121	121			121	121			121	121
TEfus+	TC4	time			44 (32, 56)	44 (32, 56)			44 (32, 56)	44 (32, 56)			44 (32, 56)	44 (32, 56)			44 (32, 56)	44 (32, 56)
TEfus+	TC4	n			5 (3, 9)	20 (10, 43)			14 (8, 28)	12 (7, 23)			9 (5, 16)	3 (1, 6)			0 (0, 0)	0 (0, 0)
TEfus+	TC4	post_p			0.43 (0.25, 0.49)	0.29 (0.06, 0.46)			0.3 (0.12, 0.47)	0.35 (0.11, 0.47)			0.35 (0.12, 0.49)	0.46 (0.38, 0.5)			0.43 (0.43, 0.43)	NA (NA, NA)
TEfus+	TC4	r_prob			0 (0, 0)	0.33 (0.33, 0.33)			0 (0, 0)	0.31 (0.31, 0.31)			0 (0, 0)	0.33 (0.33, 0.33)			0 (0, 0)	0.33 (0.33, 0.33)
TEfus+	TC4	rate			0.028 (0.014, 0.064)	0.023 (0.017, 0.034)			0.024 (0.017, 0.038)	0.022 (0.016, 0.04)			0.025 (0.014, 0.046)	0.026 (0, 0.08)			0.037 (0.037, 0.037)	0.032 (0.032, 0.032)
PI3K+	TC1	count		160		160		160		160		160		160		160		160
PI3K+	TC1	time		44 (30, 55)		44 (30, 55)		44 (30, 55)		44 (30, 55)		44 (30, 55)		44 (30, 55)		44 (30, 55)		44 (30, 55)
PI3K+	TC1	n		14 (8, 25)		16 (9, 32)		15 (8, 31)		12 (6, 24)		0 (0, 0)		3 (1, 5)		3 (0, 6)		0 (0, 0)
PI3K+	TC1	post_p		0.33 (0.1, 0.47)		0.23 (0.06, 0.46)		0.35 (0.07, 0.47)		0.34 (0.1, 0.48)		NA (NA, NA)		0.45 (0.34, 0.49)		0.44 (0.26, 0.49)		NA (NA, NA)
PI3K+	TC1	r_prob		0.27 (0.27, 0.27)		0.07 (0.07, 0.07)		0.07 (0.07, 0.07)		0.06 (0.06, 0.06)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0 (0, 0)
PI3K+	TC1	rate		0.027 (0.019, 0.043)		0.025 (0.017, 0.04)		0.028 (0.019, 0.044)		0.024 (0.016, 0.048)		NA (NA, NA)		0.032 (0.015, 0.081)		0.033 (0.02, 0.096)		0 (0, 0)
PI3K+	TC3	count		70		70		70		70		70		70		70		70
PI3K+	TC3	time		41 (30, 54)		41 (30, 54)		41 (30, 54)		41 (30, 54)		41 (30, 54)		41 (30, 54)		41 (30, 54)		41 (30, 54)
PI3K+	TC3	n		12 (7, 19)		18 (10, 36)		17 (9, 32)		10 (5, 16)		0 (0, 0)		3 (1, 5)		3 (1, 6)		0 (0, 0)
PI3K+	TC3	post_p		0.36 (0.15, 0.49)		0.31 (0.09, 0.49)		0.37 (0.15, 0.48)		0.37 (0.16, 0.48)		NA (NA, NA)		0.46 (0.38, 0.5)		0.44 (0.31, 0.49)		NA (NA, NA)
PI3K+	TC3	r_prob		0 (0, 0)		0 (0, 0)		0 (0, 0)		0.06 (0.06, 0.06)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)
PI3K+	TC3	rate		0.027 (0.018, 0.046)		0.022 (0.016, 0.033)		0.024 (0.019, 0.037)		0.023 (0.015, 0.041)		NA (NA, NA)		0.028 (0, 0.067)		0.033 (0.012, 0.082)		0.231 (0.231, 0.231)
PI3K+	TC4	count		91		91		91		91		91		91		91		91
PI3K+	TC4	time		35 (24, 53)		35 (24, 53)		35 (24, 53)		35 (24, 53)		35 (24, 53)		35 (24, 53)		35 (24, 53)		35 (24, 53)
PI3K+	TC4	n		13 (8, 22)		17 (11, 31)		14 (9, 26)		11 (7, 22)		0 (0, 0)		2 (0, 6)		3 (1, 6)		0 (0, 0)
PI3K+	TC4	post_p		0.36 (0.17, 0.48)		0.34 (0.12, 0.48)		0.34 (0.14, 0.48)		0.38 (0.18, 0.48)		NA (NA, NA)		0.45 (0.36, 0.49)		0.45 (0.36, 0.49)		NA (NA, NA)
PI3K+	TC4	r_prob		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.31 (0.31, 0.31)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)
PI3K+	TC4	rate		0.027 (0.017, 0.043)		0.021 (0.015, 0.031)		0.025 (0.018, 0.037)		0.022 (0.015, 0.038)		NA (NA, NA)		0.031 (0, 0.106)		0.03 (0.009, 0.068)		0.031 (0.006, 0.031)